Featured Research

from universities, journals, and other organizations

Stopping the flow of cancer cells promotes the spread of tumours

Date:
December 3, 2012
Source:
Asociación RUVID
Summary:
Researchers have discovered that the cellular component Prrx1 prevents cancer cells from lodging in other organs and, therefore, generating new focuses of cancer. Metastasis is the cause of more than 90% of cancer deaths. The cancer cells break away from the original tumor and spread through the body anchoring to other organs and forming new tumors called metastases. For a focus of cancer to spread to other organs, its cells undergo a process known as epithelial-mesenchymal transition (EMT) which makes them mobile and invasive, and they begin to travel through the bloodstream. However, to re-anchor to a new organ or tissue they must first recover their initial characteristics, i.e. lose mobility.

Researchers discover that the cellular component Prrx1 prevents cancer cells from lodging in other organs and, therefore, generating new focuses of cancer.
Credit: Image courtesy of Asociación RUVID

Researchers discover that the cellular component Prrx1 prevents cancer cells from lodging in other organs and, therefore, generating new focuses of cancer.

Related Articles


Metastasis is the cause of more than 90% of cancer deaths. The cancer cells break away from the original tumour and spread through the body anchoring to other organs and forming new tumours called metastases. For a focus of cancer to spread to other organs, its cells undergo a process known as epithelial-mesenchymal transition (EMT) which makes them mobile and invasive, and they begin to travel through the bloodstream. However, to re-anchor to a new organ or tissue they must first recover their initial characteristics, i.e. lose mobility.

The Institute of Neurosciences, a joint centre of the Universidad Miguel Hernández of Elche and the National Research Council (CSIC), has found that the transition from mobile to stationary cancer cell involves the loss of its component Prrx1. The researcher Ángela Nieto, who led the study, explains that "although this component is one of the factors favouring the initial spread of cancer cells and their arrival to other organs, it has to be turned off for these cells to group together to form other tumours."

Tumours with high amounts of Prrx1 have therefore better prognosis as they can not form metastases. The researcher Óscar Ocaña believes that "the therapeutic strategy of blocking the EMT to prevent the spread of tumours would only be effective if done before the first cancer cells detach from the primary tumour, which usually occurs in very early stages of the disease and usually before receiving the diagnosis." In fact, Nieto adds, "blocking the EMT in these conditions favours the appearance of new tumours." However, the research also shows that a strategy aimed at attacking other properties of cancer cells would work against metastasis.

The results have been obtained by studying various animal models: chicken, zebrafish and mouse, and by analysing patient samples. Other participants in the project include researchers from the Institute of Biomedical Research "Alberto Sols" in Madrid, the Bellvitge Biomedical Research Institute and the MD Anderson International Foundation.


Story Source:

The above story is based on materials provided by Asociación RUVID. Note: Materials may be edited for content and length.


Journal Reference:

  1. Oscar H. Ocaña, Rebeca Córcoles, Ángels Fabra, Gema Moreno-Bueno, Hervé Acloque, Sonia Vega, Alejandro Barrallo-Gimeno, Amparo Cano, M. Angela Nieto. Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1. Cancer Cell, 2012; DOI: 10.1016/j.ccr.2012.10.012

Cite This Page:

Asociación RUVID. "Stopping the flow of cancer cells promotes the spread of tumours." ScienceDaily. ScienceDaily, 3 December 2012. <www.sciencedaily.com/releases/2012/12/121203091454.htm>.
Asociación RUVID. (2012, December 3). Stopping the flow of cancer cells promotes the spread of tumours. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2012/12/121203091454.htm
Asociación RUVID. "Stopping the flow of cancer cells promotes the spread of tumours." ScienceDaily. www.sciencedaily.com/releases/2012/12/121203091454.htm (accessed March 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins