Featured Research

from universities, journals, and other organizations

New target for Alzheimer's drug development

Date:
December 3, 2012
Source:
University of Minnesota Academic Health Center
Summary:
Researchers have developed a synthetic compound that, in a mouse model, successfully prevents the neurodegeneration associated with Alzheimer's disease.

Researchers at the University of Minnesota's Center for Drug Design have developed a synthetic compound that, in a mouse model, successfully prevents the neurodegeneration associated with Alzheimer's disease.

Related Articles


In the pre-clinical study, researchers Robert Vince, Ph.D.; Swati More, Ph.D.; and Ashish Vartak, Ph.D., of the University's Center for Drug Design, found evidence that a lab-made compound known as psi-GSH enables the brain to use its own protective enzyme system, called glyoxalase, against the Alzheimer's disease process.

The discovery is published online in the American Chemical Society journal ACS Chemical Neuroscience and presents a new target for the design of anti-Alzheimer's and related drugs.

"While most other drugs under development and on the market attempt to slow down or reverse the Alzheimer's processes, our approach strikes at a root cause by enabling the brain itself to fight the disease at a very early stage," said Vince, the study's lead researcher and director of the Center for Drug Design. "As is the case with all drug development, these studies need to be replicated in human patients before coming to any firm conclusions."

Alzheimer's has previously been found to impair the ability of the brain to use the glyoxalase system. But the compound psi-GSH provides the glyoxalase system the fuel it needs to destroy destructive oxidized sugar metabolites that -- in Alzheimer's models -- converts normal brain amyloid protein into the abnormal form that produces Alzheimer's.

When given to mice genetically predisposed to develop Alzheimer's disease, psi-GSH reduced the buildup of abnormal amyloid beta protein in the brain. The buildup of this protein is a well-known feature of Alzheimer's, ultimately found in the form of plaques and tangles in the brain associated with the condition.

After being administered with psi-GSH for 11 weeks, cognitive capabilities such as memory and chemical brain health indicators in Alzheimer's-predisposed mice remained intact.

For example, the treated mice retained complete memory in a standard Alzheimer's maze test while the untreated mice lost significant memory and ability to negotiate the maze, indications consistent with symptoms of advanced Alzheimer's.

In addition, the treated mice were devoid of brain plaques while the untreated mice had significant plaque formation.

Preliminary studies indicated no observed toxicity to the brain or other vital organs from psi-GSH.


Story Source:

The above story is based on materials provided by University of Minnesota Academic Health Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Robert Vince, Swati Sudhakar More, Ashish Pramod Vartak. Restoration of Glyoxalase Enzyme Activity Precludes Cognitive Dysfunction in a Mouse Model of Alzheimer’s Disease. ACS Chemical Neuroscience, 2012; 121119091843002 DOI: 10.1021/cn3001679

Cite This Page:

University of Minnesota Academic Health Center. "New target for Alzheimer's drug development." ScienceDaily. ScienceDaily, 3 December 2012. <www.sciencedaily.com/releases/2012/12/121203150012.htm>.
University of Minnesota Academic Health Center. (2012, December 3). New target for Alzheimer's drug development. ScienceDaily. Retrieved April 22, 2015 from www.sciencedaily.com/releases/2012/12/121203150012.htm
University of Minnesota Academic Health Center. "New target for Alzheimer's drug development." ScienceDaily. www.sciencedaily.com/releases/2012/12/121203150012.htm (accessed April 22, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Wednesday, April 22, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Research Says Complex Tools Might Not Be 'Our Thing' Anymore

Research Says Complex Tools Might Not Be 'Our Thing' Anymore

Newsy (Apr. 21, 2015) The use of complex tools has often been seen as a defining characteristic of humanity, but that notion is now in question. Video provided by Newsy
Powered by NewsLook.com
Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Scientists Find Link Between Gestational Diabetes And Autism

Scientists Find Link Between Gestational Diabetes And Autism

Newsy (Apr. 17, 2015) Researchers who analyzed data from over 300,000 kids and their mothers say they&apos;ve found a link between gestational diabetes and autism. Video provided by Newsy
Powered by NewsLook.com
Video Messages Help Reassure Dementia Patients

Video Messages Help Reassure Dementia Patients

AP (Apr. 17, 2015) Family members are prerecording messages as part of a unique pilot program at the Hebrew Home in New York. The videos are trying to help victims of Alzheimer&apos;s disease and other forms of dementia break through the morning fog of forgetfulness. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins