Featured Research

from universities, journals, and other organizations

Problems with mineral metabolism linked with kidney disease progression

Date:
December 13, 2012
Source:
American Society of Nephrology (ASN)
Summary:
In a study of African Americans with kidney disease, levels of mineral metabolites rose over time; those with faster rates of kidney function decline had the greatest increases in metabolites. Higher baseline levels of metabolites were linked with an increased risk for kidney failure or death independent of kidney function. Disordered mineral metabolism is more severe in African Americans with chronic kidney disease, which might partially explain why their disease progresses more rapidly to kidney failure.

Abnormalities of mineral metabolism worsen with progressive chronic kidney disease (CKD) and are linked with a higher risk for kidney failure among African Americans, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). The findings suggest that measuring mineral metabolites may be a useful way to determine a CKD patient's prognosis, and targeting mineral metabolites may help slow progression of the disease.

It is often difficult for physicians to differentiate which patients with CKD will go on to develop advanced stages of the disease and which will remain more stable over time. They do know that CKD tends to progress more rapidly to kidney failure in African Americans than in Caucasians and that disordered mineral metabolism -- which occurs when failing kidneys do not maintain the proper levels of minerals in the blood -- is more severe among African Americans with CKD. This might partially explain the accelerated progression of their disease.

To investigate, Julia Scialla, MD, Myles Wolf, MD (University of Miami Miller School of Medicine) and their colleagues measured blood levels of various mineral metabolites over an average of four years in 420 CKD patients who participated in the African American Study of Kidney Disease and Hypertension. "We were hoping to determine whether abnormal blood levels of calcium and phosphate, and the hormones that regulate them -- fibroblast growth factor 23, vitamin D, and parathyroid hormone -- are risk factors for kidney disease progression in African American," said Dr. Wolf. The researchers also looked for a potential link between levels of these mineral metabolites at the start of the study and risk for kidney failure or death in 809 participants.

Among the major findings:

  • FGF23, PTH, and phosphate levels rose over time; the greatest increases occurred in participants with faster rates of kidney function decline.
  • Patients with the highest levels of FGF23 at the start of the study had more than a two-fold increased risk of kidney failure or death independent of kidney function compared with patients with the lowest levels. Higher blood levels of PTH and phosphate were associated with a more modestly increased risk.
  • Vitamin D insufficiency was present in 95% of participants, but lower levels were not independently linked with kidney failure or death.

The findings suggest that abnormal levels of mineral metabolites convey clinically relevant information for assessing the likely progression of CKD beyond measurements of kidney function that clinicians already monitor routinely.

"Also, it might be possible to slow kidney disease progression in African Americans using treatments that normalize mineral levels and the hormones that regulate them. Clinical trials are needed to prove this hypothesis," said Dr. Scialla.

Study co-authors include Brad Astor, PhD (University of Wisconsin School of Medicine and Public Health); Tamara Isakova, MD, Huiliang Xie, PhD (University of Miami Miller School of Medicine); and Lawrence Appel, MD (Johns Hopkins University).


Story Source:

The above story is based on materials provided by American Society of Nephrology (ASN). Note: Materials may be edited for content and length.


Cite This Page:

American Society of Nephrology (ASN). "Problems with mineral metabolism linked with kidney disease progression." ScienceDaily. ScienceDaily, 13 December 2012. <www.sciencedaily.com/releases/2012/12/121213171607.htm>.
American Society of Nephrology (ASN). (2012, December 13). Problems with mineral metabolism linked with kidney disease progression. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2012/12/121213171607.htm
American Society of Nephrology (ASN). "Problems with mineral metabolism linked with kidney disease progression." ScienceDaily. www.sciencedaily.com/releases/2012/12/121213171607.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins