Featured Research

from universities, journals, and other organizations

Congenital heart defects could have their origin during very early pregnancy

Date:
December 13, 2012
Source:
University of East Anglia
Summary:
The origins of congenital heart defects could be traced right back to the first stages of embryonic development, according to a new study.

The origins of congenital heart defects could be traced right back to the first stages of embryonic development -- according to University of East Anglia (UEA) research.

Findings published today in the journal PLOS ONE show that the beginnings of important parts of the heart can be traced to very early stages of embryo development. The research has been funded by the British Heart Foundation.

Biologists investigated chicken eggs at the gastrulation stage -- between 12 and 14 hours after fertilisation.

They found that some cells would go on to create the anterior and secondary heart fields -- after the initial formation of a primitive linear heart tube.

This method of understanding the correlation between the embryonic origin of cells and later stages of development is called 'fate mapping'.

The addition of these early cells to the growing heart is crucial as it allows the heart to develop and form other important structures including the outflow tract.

The research is the first to 'fate map' the origin of the cells which contribute to the outflow tract in early stage embryos.

Many cardiac malformations present in newborns are associated with the outflow tract and it is hoped that understanding some of the underlying causes may be helpful to affected families.

Prof Andrea Münsterberg, from the school of Biological Sciences at UEA, said: "We were researching chick embryos, but the process of development in humans is very similar. However while the gastrulation stage takes place within just a few hours in chicks, it takes a little longer in humans and happens in the third week of pregnancy.

"It is likely that what we learn in chick embryos can be applied to human development. The next step in our research will be to identify the factors, which guide these early cardiac progenitor cells to the right place at the correct time."


Story Source:

The above story is based on materials provided by University of East Anglia. Note: Materials may be edited for content and length.


Journal Reference:

  1. Esther Camp, Susanne Dietrich, Andrea Münsterberg. Fate Mapping Identifies the Origin of SHF/AHF Progenitors in the Chick Primitive Streak. PLoS ONE, 2012; 7 (12): e51948 DOI: 10.1371/journal.pone.0051948

Cite This Page:

University of East Anglia. "Congenital heart defects could have their origin during very early pregnancy." ScienceDaily. ScienceDaily, 13 December 2012. <www.sciencedaily.com/releases/2012/12/121213171754.htm>.
University of East Anglia. (2012, December 13). Congenital heart defects could have their origin during very early pregnancy. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2012/12/121213171754.htm
University of East Anglia. "Congenital heart defects could have their origin during very early pregnancy." ScienceDaily. www.sciencedaily.com/releases/2012/12/121213171754.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) — Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) — A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
Hagel Gets Preview of New High-Tech Projects

Hagel Gets Preview of New High-Tech Projects

AP (Apr. 22, 2014) — Defense Secretary Chuck Hagel is given hands-on demonstrations Tuesday of some of the newest research from DARPA _ the military's Defense Advanced Research Projects Agency program. (April 22) Video provided by AP
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) — NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins