Featured Research

from universities, journals, and other organizations

Targeting use of acid-suppressants in hospital patients

Date:
January 7, 2013
Source:
Springer
Summary:
Gastrointestinal bleeds which occur in the hospital, although rare, are a significant source of morbidity and mortality when they occur. Currently, the prophylactic use of acid-suppressive medication in non-critically ill patients in the hospital is not widely recommended. Despite this, these medications continue to be widely utilized for this purpose.

Gastrointestinal bleeds which occur in the hospital, although rare, are a significant source of morbidity and mortality when they occur. Currently, the prophylactic use of acid-suppressive medication in non-critically ill patients in the hospital is not widely recommended. Despite this, these medications continue to be widely utilized for this purpose.

Related Articles


Shoshana Herzig from the Beth Israel Deaconess Medical Center in Massachusetts, USA, and her colleagues believe that there is a group of patients whose risk of gastrointestinal bleeds is high enough to warrant the routine prescription of acid-suppressive medication, and a larger group in whom these medications can be safely withheld. The new study, which has developed a risk scoring system to identify these patients, appears online in the Journal of General Internal Medicine, published by Springer.

Recent studies have found that the risk of gastrointestinal bleeding in hospitalized, non-critically ill patients is fairly low. However, some patients will be at greater risk for this complication than others and there is currently no method available to medical staff to help identify those most likely to have a gastrointestinal bleed. The authors therefore set out to find any potential factors which might identify which patients were most at risk to help target the use of prophylactic acid-suppressive medication where it is necessary, and withhold such medication in the rest.

Herzig and her colleagues studied 75,723 admissions to a large academic medical center over a three-year period. Patients were excluded from analysis if they were admitted with gastrointestinal bleeding, developed a bleed within one day of admission, or were due to have cardiac catheterization. There were gastrointestinal bleeds in a total of 203 patients.

From their analysis, Herzig and her colleagues identified independent risk factors which increased the likelihood of a gastrointestinal bleed. These were being over 60 years of age; being male; having liver disease, acute renal failure, or sepsis; being on a medicine service; already taking prophylactic anticoagulants; and having clotting disorders. This information then enabled the authors to develop a risk scoring system to identify high-risk groups. They found that risk of bleeding increased directly in line with these clinical risk factors.

The authors emphasize the need for further studies to reproduce this data. However, their scoring system allows identification of a sub-set of patients who may benefit from prophylactic use of acid-suppressive medication, as well as a larger group in whom these medications can safely be avoided. They conclude that "with further validation at other medical centers, this scoring system may help clinicians individualize the decision to prescribe acid-suppressive medication as prophylaxis."


Story Source:

The above story is based on materials provided by Springer. Note: Materials may be edited for content and length.


Journal Reference:

  1. Shoshana J. Herzig, Michael B. Rothberg, David B. Feinbloom, Michael D. Howell, Kalon K. L. Ho, Long H. Ngo, Edward R. Marcantonio. Risk Factors for Nosocomial Gastrointestinal Bleeding and Use of Acid-Suppressive Medication in Non-Critically Ill Patients. Journal of General Internal Medicine, 2013; DOI: 10.1007/s11606-012-2296-x

Cite This Page:

Springer. "Targeting use of acid-suppressants in hospital patients." ScienceDaily. ScienceDaily, 7 January 2013. <www.sciencedaily.com/releases/2013/01/130107110530.htm>.
Springer. (2013, January 7). Targeting use of acid-suppressants in hospital patients. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2013/01/130107110530.htm
Springer. "Targeting use of acid-suppressants in hospital patients." ScienceDaily. www.sciencedaily.com/releases/2013/01/130107110530.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rural India's Low-Cost Sanitary Pad Revolution

Rural India's Low-Cost Sanitary Pad Revolution

AFP (Nov. 28, 2014) — One man hopes his invention -– a machine that produces cheap sanitary pads –- will help empower Indian women. Duration: 01:51 Video provided by AFP
Powered by NewsLook.com
Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) — In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins