Featured Research

from universities, journals, and other organizations

Detrimental effect of obesity on lesions associated with Alzheimer's disease

Date:
January 7, 2013
Source:
INSERM (Institut national de la santé et de la recherche médicale)
Summary:
Researchers have recently used a neurodegeneration model of Alzheimer's disease to provide experimental evidence of the relationship between obesity and disorders linked to the tau protein. This research corroborates the theory that metabolic anomalies contribute massively to the development of dementia.

Researchers from Inserm and the Université Lille/Université Lille Nord de France have recently used a neurodegeneration model of Alzheimer's disease to provide experimental evidence of the relationship between obesity and disorders linked to the tau protein.

Related Articles


This research was conducted on mice and is published in the Diabetes review: it corroborates the theory that metabolic anomalies contribute massively to the development of dementia.

In France, more than 860,000 people suffer from Alzheimer's disease and related disorders, making them the largest cause of age-related loss of intellectual function. Cognitive impairments observed in Alzheimer's disease result from the accumulation of abnormal tau proteins in nerve cells undergoing degeneration (see the picture below). We know that obesity, a major risk factor in the development of insulin resistance and type 2 diabetes, increases the risk of dementia during the aging process. However, the effects of obesity on 'Taupathies' (i.e. tau protein-related disorders), including Alzheimer's disease, were not clearly understood. In particular, researchers assumed that insulin resistance played a major role in terms of the effects of obesity.

The "Alzheimer & Tauopathies" team from mixed research unit 837 (Inserm/Université Lille 2/Université Lille Nord de France) directed by Dr. Luc Buée, in collaboration with mixed research unit 1011 "Nuclear receptors, cardiovascular diseases and diabetes," have just demonstrated, in mice, that obese subjects develop aggravated disorders. To achieve this result, young transgenic mice, who develop tau-related neurodegeneration progressively with age, were put on a high-fat diet for five months, leading to progressive obesity.

"At the end of this diet, the obese mice had developed an aggravated disorder both from the point of view of memory and modifications to the Tau protein," explains David Blum, in charge of research at Inserm.

This study uses a neurodenegeneration model of Alzheimer's disease to provide experimental evidence of the relationship between obesity and disorders linked to the tau protein. Furthermore, it indicates that insulin resistance is not the aggravating factor, as was suggested in previous studies.

"Our research supports the theory that environmental factors contribute massively to the development of this neurodegenerative disorder" underlines the researcher. "Our work is now focussing on identifying the factors responsible for this aggravation" he adds.

This research was supported by LabEx DISTALZ (development of Innovative Strategies for a Transdisciplinary Approach to Alzheimer's Disease) within the framework of future investments.


Story Source:

The above story is based on materials provided by INSERM (Institut national de la santé et de la recherche médicale). Note: Materials may be edited for content and length.


Journal Reference:

  1. A. Leboucher, C. Laurent, F.-J. Fernandez-Gomez, S. Burnouf, L. Troquier, S. Eddarkaoui, D. Demeyer, R. Caillierez, N. Zommer, E. Vallez, K. Bantubungi, C. Breton, P. Pigny, V. Buee-Scherrer, B. Staels, M. Hamdane, A. Tailleux, L. Buee, D. Blum. Detrimental Effects of Diet-Induced Obesity on   Pathology Is Independent of Insulin Resistance in   Transgenic Mice. Diabetes, 2012; DOI: 10.2337/db12-0866

Cite This Page:

INSERM (Institut national de la santé et de la recherche médicale). "Detrimental effect of obesity on lesions associated with Alzheimer's disease." ScienceDaily. ScienceDaily, 7 January 2013. <www.sciencedaily.com/releases/2013/01/130107121053.htm>.
INSERM (Institut national de la santé et de la recherche médicale). (2013, January 7). Detrimental effect of obesity on lesions associated with Alzheimer's disease. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2013/01/130107121053.htm
INSERM (Institut national de la santé et de la recherche médicale). "Detrimental effect of obesity on lesions associated with Alzheimer's disease." ScienceDaily. www.sciencedaily.com/releases/2013/01/130107121053.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) — The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) — An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins