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Why Down syndrome boosts susceptibility to other conditions

Date:
January 11, 2013
Source:
University of California - Irvine
Summary:
A new study has revealed some of the underlying neural factors that explain why people with Down syndrome are more susceptible to Alzheimer's disease, diabetes and autistic spectrum disorders.

A study led by UC Irvine researchers has revealed some of the underlying neural factors that explain why people with Down syndrome are more susceptible to Alzheimer's disease, diabetes and autistic spectrum disorders. Jorge Busciglio, associate professor of neurobiology & behavior, and colleagues analyzed the cellular and molecular mechanisms leading to oxidative stress and mitochondrial dysfunction in Down syndrome individuals.

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They found that this breakdown in energy metabolism within brain cells contributes to the higher probability of these other conditions.

Down syndrome occurs when a person has 47 chromosomes instead of the usual 46. Estimates suggest that 25 percent or more of individuals over 35 with Down syndrome show signs of Alzheimer's-type dementia. This percentage increases with age.

The incidence of Alzheimer's disease in people with Down syndrome is roughly three to five times greater than in the general population. Pablo Helguera, Jaqueline Seiglie and Michael Hanna of UC Irvine; Jose Rodriguez of UCLA; and Gustavo Helguera of Argentina's University of Buenos Aires also contributed to the study, which appears in the Jan. 8 issue of Cell Metabolism and was supported by the Larry L. Hillblom Foundation and the National Institutes of Health.


Story Source:

The above story is based on materials provided by University of California - Irvine. Note: Materials may be edited for content and length.


Journal Reference:

  1. Pablo Helguera, Jaqueline Seiglie, Jose Rodriguez, Michael Hanna, Gustavo Helguera, Jorge Busciglio. Adaptive Downregulation of Mitochondrial Function in Down Syndrome. Cell Metabolism, 2013; 17 (1): 132 DOI: 10.1016/j.cmet.2012.12.005

Cite This Page:

University of California - Irvine. "Why Down syndrome boosts susceptibility to other conditions." ScienceDaily. ScienceDaily, 11 January 2013. <www.sciencedaily.com/releases/2013/01/130111092729.htm>.
University of California - Irvine. (2013, January 11). Why Down syndrome boosts susceptibility to other conditions. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2013/01/130111092729.htm
University of California - Irvine. "Why Down syndrome boosts susceptibility to other conditions." ScienceDaily. www.sciencedaily.com/releases/2013/01/130111092729.htm (accessed December 19, 2014).

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