Featured Research

from universities, journals, and other organizations

Scientists seek out cancer cells hiding from treatment

Date:
January 16, 2013
Source:
Imperial College London
Summary:
Funding to improve leukemia treatment will investigate how cancer cells hide to avoid chemotherapy drugs.

Scientists believe lymphoma cells (red) hide in compartments in the bone.
Credit: Image courtesy of Imperial College London

Funding to improve leukemia treatment will investigate how cancer cells hide to avoid chemotherapy drugs.

Scientists hope to improve leukemia treatment by investigating how cancer cells use 'hiding places' in the body to avoid chemotherapy drugs.

Each year 300 British children are diagnosed with acute lymphoblastic leukemia, a cancer of the blood. The majority respond well to current therapies, but the disease returns in a quarter of patients. The long term outlook for adults is much worse, with initial treatments being effective in fewer than half of all patients.

Now, researchers from Imperial College London will begin a three year project to explore how some cancer cells evade treatment, thanks to new funding from blood cancer charity Leukemia & Lymphoma Research.

Lead researcher, Dr Cristina Lo Celso, Lecturer in Immunology in Imperial's Department of Life Sciences, said: "We believe that some evasive cancer cells hide in protective compartments inside the body while patients receive treatment. If we understand where the cancer cells hide, we will be able to develop better ways to treat patients by eliminating all cancer cells and avoiding disease relapse."

Blood cells are produced in the bone marrow, where they grow and take on a variety of forms within compartments called niches inside bones. Dr Lo Celso’s team believe that in the bones of Leukemia patients, some of these compartments have been 'hijacked' by leukemia cells, where they serve as effective hiding places during treatment. "Once we can see how this happens drugs can be developed that target the hiding places. This will have a dramatic impact on the design of new drugs for blood cancers like acute lymphoblastic leukemia," she said.

Dr Lo Celso and colleague Dr Edwin Hawkins will use high powered microscopes in Imperial's Facility for Imaging by Light Microscopy (FILM) to observe cancer cells using fluorescent light. They will use this technique to track the movement of the evasive leukemia cells in laboratory mice and hope to learn where these cells go during cancer treatment.

Professor Chris Bunce, Research Director at Leukemia & Lymphoma Research, said: "Leukemia occurs when the machinery that controls how blood cells grow and die breaks down. We now know that both normal blood cells and leukemia cells are produced by a small number of stem cells that live inside compartments in our bone marrow. Understanding how these leukemia cells hide from powerful anti-cancer drugs is vital to creating treatments for patients that will work faster and prevent the disease from returning."


Story Source:

The above story is based on materials provided by Imperial College London. Note: Materials may be edited for content and length.


Cite This Page:

Imperial College London. "Scientists seek out cancer cells hiding from treatment." ScienceDaily. ScienceDaily, 16 January 2013. <www.sciencedaily.com/releases/2013/01/130116090121.htm>.
Imperial College London. (2013, January 16). Scientists seek out cancer cells hiding from treatment. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2013/01/130116090121.htm
Imperial College London. "Scientists seek out cancer cells hiding from treatment." ScienceDaily. www.sciencedaily.com/releases/2013/01/130116090121.htm (accessed September 30, 2014).

Share This



More Health & Medicine News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Newsy (Sep. 30, 2014) The CDC says a new case of Ebola has not been reported in Nigeria for more than 21 days, leading to hopes the outbreak might be nearing its end. Video provided by Newsy
Powered by NewsLook.com
UN Ebola Mission Head: Immediate Action Is Crucial

UN Ebola Mission Head: Immediate Action Is Crucial

AFP (Sep. 30, 2014) The newly appointed head of the United Nations Mission for Ebola Emergency Response (UNMEER), Anthony Banbury, outlines operations to tackle the virus. Duration: 00:39 Video provided by AFP
Powered by NewsLook.com
CDC Confirms First Case of Ebola in US

CDC Confirms First Case of Ebola in US

AP (Sep. 30, 2014) The CDC has confirmed the first diagnosed case of Ebola in the United States. The patient is being treated at a Dallas hospital after traveling earlier this month from Liberia. (Sept. 30) Video provided by AP
Powered by NewsLook.com
New Breast Cancer Drug Extends Lives In Clinical Trial

New Breast Cancer Drug Extends Lives In Clinical Trial

Newsy (Sep. 30, 2014) In a clinical trial, breast cancer patients lived an average of 15 months longer when they received new drug Perjeta along with Herceptin. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins