Featured Research

from universities, journals, and other organizations

Scientists seek out cancer cells hiding from treatment

Date:
January 16, 2013
Source:
Imperial College London
Summary:
Funding to improve leukemia treatment will investigate how cancer cells hide to avoid chemotherapy drugs.

Scientists believe lymphoma cells (red) hide in compartments in the bone.
Credit: Image courtesy of Imperial College London

Funding to improve leukemia treatment will investigate how cancer cells hide to avoid chemotherapy drugs.

Scientists hope to improve leukemia treatment by investigating how cancer cells use 'hiding places' in the body to avoid chemotherapy drugs.

Each year 300 British children are diagnosed with acute lymphoblastic leukemia, a cancer of the blood. The majority respond well to current therapies, but the disease returns in a quarter of patients. The long term outlook for adults is much worse, with initial treatments being effective in fewer than half of all patients.

Now, researchers from Imperial College London will begin a three year project to explore how some cancer cells evade treatment, thanks to new funding from blood cancer charity Leukemia & Lymphoma Research.

Lead researcher, Dr Cristina Lo Celso, Lecturer in Immunology in Imperial's Department of Life Sciences, said: "We believe that some evasive cancer cells hide in protective compartments inside the body while patients receive treatment. If we understand where the cancer cells hide, we will be able to develop better ways to treat patients by eliminating all cancer cells and avoiding disease relapse."

Blood cells are produced in the bone marrow, where they grow and take on a variety of forms within compartments called niches inside bones. Dr Lo Celso’s team believe that in the bones of Leukemia patients, some of these compartments have been 'hijacked' by leukemia cells, where they serve as effective hiding places during treatment. "Once we can see how this happens drugs can be developed that target the hiding places. This will have a dramatic impact on the design of new drugs for blood cancers like acute lymphoblastic leukemia," she said.

Dr Lo Celso and colleague Dr Edwin Hawkins will use high powered microscopes in Imperial's Facility for Imaging by Light Microscopy (FILM) to observe cancer cells using fluorescent light. They will use this technique to track the movement of the evasive leukemia cells in laboratory mice and hope to learn where these cells go during cancer treatment.

Professor Chris Bunce, Research Director at Leukemia & Lymphoma Research, said: "Leukemia occurs when the machinery that controls how blood cells grow and die breaks down. We now know that both normal blood cells and leukemia cells are produced by a small number of stem cells that live inside compartments in our bone marrow. Understanding how these leukemia cells hide from powerful anti-cancer drugs is vital to creating treatments for patients that will work faster and prevent the disease from returning."


Story Source:

The above story is based on materials provided by Imperial College London. Note: Materials may be edited for content and length.


Cite This Page:

Imperial College London. "Scientists seek out cancer cells hiding from treatment." ScienceDaily. ScienceDaily, 16 January 2013. <www.sciencedaily.com/releases/2013/01/130116090121.htm>.
Imperial College London. (2013, January 16). Scientists seek out cancer cells hiding from treatment. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2013/01/130116090121.htm
Imperial College London. "Scientists seek out cancer cells hiding from treatment." ScienceDaily. www.sciencedaily.com/releases/2013/01/130116090121.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins