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H1N1 flu shots appear safe for pregnant women: Pandemic vaccination did not increase risk of fetal death

Date:
January 17, 2013
Source:
Norwegian Institute of Public Health
Summary:
Pregnant women who were vaccinated against pandemic influenza were not at increased risk of experiencing fetal death. However, pregnant women who contracted influenza had an increased risk of fetal death. This was found in a register study of women who were pregnant during the influenza pandemic in 2009.

Pregnant women who were vaccinated against pandemic influenza were not at increased risk of experiencing fetal death.
Credit: © Tatyana Gladskih / Fotolia

Pregnant women who were vaccinated against pandemic influenza were not at increased risk of experiencing fetal death. However, pregnant women who contracted influenza had an increased risk of fetal death. This was found in a register study of women who were pregnant during the influenza pandemic in 2009.

The study is published in the New England Journal of Medicine.

During the swine influenza pandemic, there were anecdotal reports of miscarriages and stillbirths occurring shortly after vaccination. Therefore, the Norwegian Institute of Public Health initiated a study to investigate if there was an association between pandemic influenza vaccination and fetal death.

Pregnant women are at increased risk of severe influenza infection. Previous studies have shown that pregnant women who were hospitalised with influenza had increased risk of fetal death. The researchers were interested in whether pandemic influenza also increased the risk of fetal death among pregnant women who were not admitted to hospital.

"Norway is one of very few countries that have the opportunity to study these issues because of our excellent health registers. The registers include information about pregnancy and pandemic vaccination," says Dr. Camilla Stoltenberg, Director General of the Norwegian Institute of Public Health.

During the influenza A(H1N1) pandemic of 2009, the entire Norwegian population was offered the pandemic vaccine Pandemrix. Approximately 45 per cent were vaccinated. More than half (54 per cent) of those pregnant during the pandemic took the vaccine.

The study included more than 117,000 births in Norway occurring before, during and after the pandemic. Nearly 26,000 women were vaccinated against pandemic influenza while pregnant.

When analysing the data, the researchers took into account the timing of vaccination or influenza in pregnancy and the duration of each pregnancy.

Main findings

  • Pregnant women who were vaccinated did not have increased risk of fetal death.
  • Pregnant women who were vaccinated had a considerably reduced risk of influenza.
  • Pregnant women who were diagnosed with influenza during the pandemic had almost doubled risk of fetal death.

The Medical Birth Registry of Norway collects information about fetal death after week 12 of pregnancy, so the researchers could not examine early losses. Fetal death is rare in Norway (about 5 per 1000 births). Although this study found an increased risk after influenza, few pregnancies end in fetal death.

The results from this large study are in line with smaller studies from Denmark and Canada that also indicate that the pandemic vaccine was not associated with increased risk of fetal death.

"It is reassuring that such a large and comprehensive study did not find any evidence that vaccination increased the risk of fetal death," says Dr. Stoltenberg. "The results suggest that influenza during pregnancy can be detrimental for the fetus, even if the mother is not seriously ill and admitted to hospital," she adds.

"We recommend that pregnant women are vaccinated against influenza. In addition to protecting the mother, the vaccine protects the child in the first months after birth, at a time when the child is too young to be vaccinated," says Dr. Stoltenberg.


Story Source:

The above story is based on materials provided by Norwegian Institute of Public Health. Note: Materials may be edited for content and length.


Journal Reference:

  1. Siri E. Håberg, Lill Trogstad, Nina Gunnes, Allen J. Wilcox, Håkon K. Gjessing, Sven Ove Samuelsen, Anders Skrondal, Inger Cappelen, Anders Engeland, Preben Aavitsland, Steinar Madsen, Ingebjørg Buajordet, Kari Furu, Per Nafstad, Stein Emil Vollset, Berit Feiring, Hanne Nøkleby, Per Magnus, Camilla Stoltenberg. Risk of Fetal Death after Pandemic Influenza Virus Infection or Vaccination. New England Journal of Medicine, 2013; 130116140046009 DOI: 10.1056/NEJMoa1207210

Cite This Page:

Norwegian Institute of Public Health. "H1N1 flu shots appear safe for pregnant women: Pandemic vaccination did not increase risk of fetal death." ScienceDaily. ScienceDaily, 17 January 2013. <www.sciencedaily.com/releases/2013/01/130117084731.htm>.
Norwegian Institute of Public Health. (2013, January 17). H1N1 flu shots appear safe for pregnant women: Pandemic vaccination did not increase risk of fetal death. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2013/01/130117084731.htm
Norwegian Institute of Public Health. "H1N1 flu shots appear safe for pregnant women: Pandemic vaccination did not increase risk of fetal death." ScienceDaily. www.sciencedaily.com/releases/2013/01/130117084731.htm (accessed September 23, 2014).

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