Featured Research

from universities, journals, and other organizations

New technology shows diabetes

Date:
January 21, 2013
Source:
Ume universitet
Summary:
A new imaging method for the study of insulin-producing cells in diabetes among other uses has been developed.

Near-infrared optical projection tomography enables the visualization of several cell types in large preparations. The image of a pancreas from a mouse with type-1 diabetes shows the insulin-producing islets of Langerhans in blue, blood vessels in red, and infiltrating autoimmune cells that break down the insulin-producing cells in green.
Credit: Image courtesy of Ume universitet

A new imaging method for the study of insulin-producing cells in diabetes among other uses is now being presented by a group of researchers at Ume University in Sweden in the form of a video in the biomedical video journal, The Journal of Visualized Experiments.

Professor Ulf Ahlgren and his associates at the Ume Center for Molecular Medicine (UCMM) have developed technology for biomedical imaging with optical projection tomography (OPT). Initially the method could only be used on relatively small preparations, but five years ago the scientists at Ume were able to adapt the technology to study whole organs including the pancreas from adult mice. The present findings describe a further development of the OPT technology by going from ordinary visible light to the near-infrared spectrum. Near infrared light is light with longer wavelengths that can more easily penetrate tissue. Thereby, the developed imaging platform enables studies of considerably larger samples than was previously possible. This includes the rat pancreas, which is important because rats as laboratory animals are thought to be physiologically more similar to humans.

This adaptation, to be able to also image in near-infrared light, also means that the researchers gain access to a broader range of the light spectrum, making it possible to study more and different cell types in one organ preparation. In the article the scientists exemplify the possibility of simultaneously tracking the insulin-producing islets of Langerhans as well as the autoimmune infiltrating cells and the distribution of blood vessels in a model system for type-1 diabetes.

Internationally, huge resources are being committed to the development of non-invasive imaging methods for study of the number of remaining insulin cells in patients with developing diabetes. Such methods would be of great importance as only indirect methods for this exist today. However, a major problem in these research undertakings is to find suitable contrast agents that specifically bind to the insulin producing cells of the pancreas to allow imaging. In this context, the developed Near Infrared -- OPT technology can play an important role as it enables the evaluation of new contrast agents. It may also be used as a tool to calibrate the non-invasive read out by e.g. magnetic resonance imaging (MRI).

This is now going to be tested in the newly launched Marie Curie project "European Training Network for Excellence in Molecular Imaging in Diabetes," which links together five major EU-funded research consortia with different cutting-edge competences in the field.

The developed techniques have contributed to the reasons why the research team recently received a SEK 4.3 million grant from the EU in a Marie Curie program to link together leading research teams in Europe in the field of diabetes imaging.


Story Source:

The above story is based on materials provided by Ume universitet. Note: Materials may be edited for content and length.


Journal Reference:

  1. Anna U Eriksson, Christoffer Svensson, Andreas Hrnblad, Abbas Cheddad, Elena Kostromina, Maria Eriksson, Nils Norlin, Antonello Pileggi, James Sharpe, Fredrik Georgsson, Tomas Alanentalo, Ulf Ahlgren. Near Infrared Optical Projection Tomography for Assessments of β-cell Mass Distribution in Diabetes Research. Journal of Visualized Experiments, 2013; (71) DOI: 10.3791/50238

Cite This Page:

Ume universitet. "New technology shows diabetes." ScienceDaily. ScienceDaily, 21 January 2013. <www.sciencedaily.com/releases/2013/01/130121083033.htm>.
Ume universitet. (2013, January 21). New technology shows diabetes. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2013/01/130121083033.htm
Ume universitet. "New technology shows diabetes." ScienceDaily. www.sciencedaily.com/releases/2013/01/130121083033.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins