Featured Research

from universities, journals, and other organizations

Harmful effects of bisphenol A demonstrated experimentally

Date:
January 22, 2013
Source:
INSERM (Institut national de la santé et de la recherche médicale)
Summary:
Weak concentrations of bisphenol A are sufficient to produce a negative reaction on the human testicle. This has just been shown experimentally.

System for culturing fetal testicles developed by René Habert’s team. The testicles are sliced into tiny fragments then deposited on a filter in the centre of a petri dish. In an appropriate atmosphere, they are able to survive thus for several days, while secreting testosterone.
Credit: R habert/Inserm

Weak concentrations of bisphenol A are sufficient to produce a negative reaction on the human testicle. This has just been shown experimentally for the first time by René Habert and his colleagues (UMR Cellules souches et Radiations [UMR Stem Cells and Radiation], Inserm U 967 -- CEA -- Paris Diderot University) in an article that appeared in the journal entitled PLoS One.

Related Articles


Bisphenol A (BPA) is a chemical compound that is included in the composition of plastics and resins. It is used, for example, in the manufacture of food containers such as bottles and babies' feeding bottles. It is also found in the protective films used inside food and drink cans and on till receipts where it used as a discloser. Significant levels of BPA have also been found in human blood, urine, amniotic fluid and placentas. Recent studies have shown that this industrial component has harmful effects on reproductive ability, development and the metabolism of laboratory animals. BPA is strongly suspected of having the same effects on humans.

As a precautionary measure, the manufacture and sale of babies' feeding bottles containing bisphenol A have been banned in Europe since January 2011. This ban will be extended in France to all food containers from July 2015. It will also be important to ensure that in the future, bisphenol A is not replaced by substitutes that have the same action.

System for culturing fetal testicles developed by René Habert's team. The testicles are sliced into tiny fragments then deposited on a filter in the centre of a petri dish. In an appropriate atmosphere, they are able to survive thus for several days, while secreting testosterone.

In an article published in Plos One, René Habert and his colleagues provide the first experimental proof that weak concentrations of bisphenol A are sufficient to produce a negative reaction on the human testicle.

No experimental study has shown hitherto that bisphenol A has a deleterious effect on male human reproduction and the few epidemiological studies that exist remain contradictory.

In collaboration with the Antoine-Béclère Hospital, Clamart1, researchers kept petri dishes of human fetal testicles alive in the presence of bisphenol A or in the absence thereof, using an original procedure developed by this team. In 2009, this procedure made it possible to show for the first time, that phtalates (a different category of endocrine disruptors2 that are found in PVC, plastics, synthetic materials, sprays, etc.) inhibit the development of future spermatozoa in the human fœtus.

In this new study, researchers observed that exposure of human fetal testicles to bisphenol A reduces the production of testosterone, and of another testicular hormone that is necessary for the testicles to descend into the sacs in the course of fetal development. A concentration equal to 2 micrograms per litre of bisphenol A in the culture medium was sufficient to produce these effects. This concentration is equal to the average concentration generally found in the blood, urine and amniotic fluid of the population.

Testosterone is known to be produced by the testicle during the life of the fœtus, imposing masculinisation of the internal and external genitals which, in the absence of testosterone, develops spontaneously in the female direction. Furthermore, it is likely that testosterone also plays a role in the development of the testicle itself. Consequently, the current exposure of pregnant women to bisphenol A may be one of the causes of congenital masculinisation defects (of the hypospadia and cryptorchidism types) the frequency of which has doubled overall in the past 40 years. According to René Habert, "it is also possible that bisphenol A contributes to a reduction in the production of sperm and the increase in the incidence of testicular cancer in adults that have been observed in recent decades."

Furthermore, researchers have compared the response to bisphenol A in human fetal testicles to those in the fetal testicles of rats and mice. "We have observed that the human species is far more sensitive to bisphenol A than the rat and the mouse. These results should encourage greater caution in regulatory toxicology in the extrapolation of data obtained on animals to define tolerable exposure thresholds in human health", explains René Habert.

Finally, the researchers show in this article that Bisphenol A acts through a mechanism that is non-standard and that remains unknown but that it is important to identify in order to better understand the action of endocrine disruptors.


Story Source:

The above story is based on materials provided by INSERM (Institut national de la santé et de la recherche médicale). Note: Materials may be edited for content and length.


Journal Reference:

  1. Thierry N’Tumba-Byn, Delphine Moison, Marlène Lacroix, Charlotte Lecureuil, Laëtitia Lesage, Sophie M. Prud’homme, Stéphanie Pozzi-Gaudin, René Frydman, Alexandra Benachi, Gabriel Livera, Virginie Rouiller-Fabre, René Habert. Differential Effects of Bisphenol A and Diethylstilbestrol on Human, Rat and Mouse Fetal Leydig Cell Function. PLoS ONE, 2012; 7 (12): e51579 DOI: 10.1371/journal.pone.0051579

Cite This Page:

INSERM (Institut national de la santé et de la recherche médicale). "Harmful effects of bisphenol A demonstrated experimentally." ScienceDaily. ScienceDaily, 22 January 2013. <www.sciencedaily.com/releases/2013/01/130122101913.htm>.
INSERM (Institut national de la santé et de la recherche médicale). (2013, January 22). Harmful effects of bisphenol A demonstrated experimentally. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2013/01/130122101913.htm
INSERM (Institut national de la santé et de la recherche médicale). "Harmful effects of bisphenol A demonstrated experimentally." ScienceDaily. www.sciencedaily.com/releases/2013/01/130122101913.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) — The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) — Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) — Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) — Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins