Featured Research

from universities, journals, and other organizations

Chronic kidney disease increases risk of death for both women and men

Date:
January 30, 2013
Source:
Johns Hopkins University Bloomberg School of Public Health
Summary:
A new study found that in general chronic kidney disease is associated with a higher risk of death and end stage renal disease for both women and men.

A new study from the Johns Hopkins Bloomberg School of Public Health and the Chronic Kidney Disease Prognosis Consortium (CKD-PC) found that in general chronic kidney disease is similarly associated with a higher risk of death and end stage renal disease for both women and men.

Chronic kidney disease affects 10 to 16 percent of adults worldwide. Current thresholds for chronic kidney disease are based on two kidney measures, estimated glomerular filtration rate (GFR) and albuminuria, a measure of protein in the urine. Because mildly reduced GFR is more common in women, and both kidney measures are affected by muscle mass, some have suggested that the definition of chronic kidney disease should be sex-specific.

According to the study, the overall risks of all-cause mortality and cardiovascular mortality were higher in men at all levels of kidney function. However, both sexes experienced increased risks of all-cause mortality, cardiovascular mortality, and end stage renal disease with lower estimated glomerular filtration rate and higher albuminuria, with only a slight difference in the strength of relationships between sexes.

"Our results contrast with some previous studies suggesting that the association of estimated glomerular filtration rate with mortality is weaker in women. We found the association between chronic kidney disease and mortality risk to be as strong in women as in men. Low estimated glomerular filtration rate or albuminuria should be considered at least as potent a risk factor in women as it is in men," said Josef Coresh, MD, PhD, MHS, the Consortium's principal investigator and professor in the Bloomberg School's Department of Epidemiology.

For the study, researchers analyzed data from more than 2 million participants from 46 cohort studies. The study participants included a diverse population from Asia, Australia, Europe, and North and South America. Fifty-four percent of the study populations were women.

"Associations of estimated glomerular filtration rate and albuminuria with mortality and renal failure by sex: a meta-analysis" was written by the CKD-PC, which includes approximately 200 collaborators and data from 40 countries.

Funding sources include the National Kidney Foundation for the CKD-PC and a variety of sources such as the National Institutes of Health, medical research councils, foundations, and industry sponsors for collaborating authors and cohorts.


Story Source:

The above story is based on materials provided by Johns Hopkins University Bloomberg School of Public Health. Note: Materials may be edited for content and length.


Journal Reference:

  1. D. Nitsch, M. Grams, Y. Sang, C. Black, M. Cirillo, O. Djurdjev, K. Iseki, S. K. Jassal, H. Kimm, F. Kronenberg, C. M. Oien, A. S. Levey, A. Levin, M. Woodward, B. R. Hemmelgarn. Associations of estimated glomerular filtration rate and albuminuria with mortality and renal failure by sex: a meta-analysis. BMJ, 2013; 346 (jan29 1): f324 DOI: 10.1136/bmj.f324

Cite This Page:

Johns Hopkins University Bloomberg School of Public Health. "Chronic kidney disease increases risk of death for both women and men." ScienceDaily. ScienceDaily, 30 January 2013. <www.sciencedaily.com/releases/2013/01/130130132417.htm>.
Johns Hopkins University Bloomberg School of Public Health. (2013, January 30). Chronic kidney disease increases risk of death for both women and men. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2013/01/130130132417.htm
Johns Hopkins University Bloomberg School of Public Health. "Chronic kidney disease increases risk of death for both women and men." ScienceDaily. www.sciencedaily.com/releases/2013/01/130130132417.htm (accessed September 20, 2014).

Share This



More Health & Medicine News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins