Featured Research

from universities, journals, and other organizations

Anti-Müllerian hormone predicts IVF success

Date:
February 12, 2013
Source:
Endocrine Society
Summary:
Women with a high concentration of anti-Müllerian hormone stand a better chance of giving birth after in vitro fertilization, according to a recent study.

Women with a high concentration of anti-Müllerian hormone stand a better chance of giving birth after in vitro fertilization, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

Anti-Müllerian hormone (AMH) is produced by the ovaries. The study found women with high AMH levels were 2.5 times more likely to have a successful IVF cycle than women of a similar age with low levels of the hormone. AMH levels were a predictor of pregnancy and live birth, even when the mother's age and egg production were taken into account.

Although a growing body of research has pinpointed AMH levels as an indicator of the number of eggs remaining in a woman's ovaries, this study is the first to demonstrate AMH levels are directly connected to birth and pregnancy rates, regardless of the number of eggs retrieved.

"For women who are struggling to get pregnant, a high AMH level should be very reassuring," said Thomas Brodin, MD, of Uppsala University in Sweden and lead author of the study. "High levels of this hormone mean there is a greater chance they have plenty of healthy eggs remaining to support a pregnancy."

Researchers concluded high AMH levels are associated with successful IVF treatment because the hormone levels reveal important information about the quality as well as the quantity of eggs left in a woman's ovaries. Women who have high AMH levels are likely to have a high proportion of eggs capable of developing into healthy embryos, Brodin said.

The prospective cohort study tracked 892 women who underwent IVF treatment at the Carl von Linné Clinic in Uppsala between 2008 and 2011. The participants underwent a total of 1,230 IVF cycles. AMH levels in the participants' blood were measured prior to treatment.

The study found that women were more likely to have a successful treatment outcome as their AMH levels increased. Women who had AMH levels above 2.94 ng/ml had the highest birth rates. The effect leveled out when AMH levels surpassed 5 ng/ml.

Although researchers did not find a cut-off point below which women could not get pregnant, IVF success rates dropped substantially as AMH levels declined. Among the study participants who had AMH levels below 0.2 ng/ml, 53 IVF cycles resulted in only 18 embryo transfers and the birth of three children.

The study found reason for optimism among women who have polycystic ovary syndrome, a condition normally associated with ovulation problems. Women who have this condition tend to have high AMH levels.

"Our data suggests women who have polycystic ovaries are likely to be good candidates for IVF," Brodin said. "Along with high AMH levels, this group tends to have a significant supply of eggs remaining in the ovaries."

Other researchers working on the study include: N. Hadziosmanovic and L. Berglund of Uppsala Clinical Research Center, and M. Olovsson and J. Holte of Uppsala University.


Story Source:

The above story is based on materials provided by Endocrine Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. S. L. Broer, M. J. C. Eijkemans, G. J. Scheffer, I. A. J. van Rooij, A. de Vet, A. P. N. Themmen, J. S. E. Laven, F. H. de Jong, E. R. te Velde, B. C. Fauser, F. J. M. Broekmans. Anti-Mullerian Hormone Predicts Menopause: A Long-Term Follow-Up Study in Normoovulatory Women. Journal of Clinical Endocrinology & Metabolism, 2011; 96 (8): 2532 DOI: 10.1210/jc.2010-2776

Cite This Page:

Endocrine Society. "Anti-Müllerian hormone predicts IVF success." ScienceDaily. ScienceDaily, 12 February 2013. <www.sciencedaily.com/releases/2013/02/130212075111.htm>.
Endocrine Society. (2013, February 12). Anti-Müllerian hormone predicts IVF success. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2013/02/130212075111.htm
Endocrine Society. "Anti-Müllerian hormone predicts IVF success." ScienceDaily. www.sciencedaily.com/releases/2013/02/130212075111.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) — Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) — Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Newsy (July 30, 2014) — The Peace Corps is one of several U.S.-based organizations to pull workers out of West Africa because of the Ebola outbreak. Video provided by Newsy
Powered by NewsLook.com
Weather Kills 2K A Year, But Storms Aren't The Main Offender

Weather Kills 2K A Year, But Storms Aren't The Main Offender

Newsy (July 30, 2014) — Health officials say 2,000 deaths occur each year in the U.S. due to weather, but it's excessive heat and cold that claim the most lives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:  

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile iPhone Android Web
      Follow Facebook Twitter Google+
      Subscribe RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins