Featured Research

from universities, journals, and other organizations

Clues to childhood respiratory virus: Human metapneumovirus

Date:
February 13, 2013
Source:
Vanderbilt University Medical Center
Summary:
New research has identified the relatively unknown human metapneumovirus (MPV) as the second most common cause of severe bronchiolitis in young children.

New Vanderbilt-led research published in the Feb. 14 issue of the New England Journal of Medicine has identified the relatively unknown human metapneumovirus (MPV) as the second most common cause of severe bronchiolitis in young children.

Related Articles


Senior author John Williams, M.D., associate professor of Pediatric Infectious Diseases and a well-known expert in MPV research, said it is gratifying to offer a clearer picture of how this virus impacts children.

"We found MPV is as important a cause of respiratory illness as influenza, and caused more illness than the three common types of parainfluenza virus combined. In fact, in young children, the burden of MPV was second only to RSV (respiratory syncytial virus) as a cause of bronchiolitis," Williams said.

The prospective research spanned six years, from 2003 to 2009, and involved samples taken from more than 10,000 children under age 5. The children were hospitalized, treated in an emergency department, or seen in an outpatient clinic with a lower respiratory infection (bronchiolitis).

Lead author Kathryn Edwards, M.D., the Sarah H. Sell and Cornelius Vanderbilt Chair in Pediatrics and director of the Vanderbilt Vaccine Research Program, led the clinical portion of the study while Williams' laboratory tested the samples for their viral content.

Three New Vaccine Surveillance Network (NVSN) sites participated: Rochester, N.Y., Cincinnati and Nashville, making this the largest prospective trial to date to investigate the burden of MPV.

Researchers found MPV tends to affect more children over age 1 than RSV, and while both viral infections strike in late winter or spring, MPV has a seasonal peak that lags behind the typical peak for RSV by about a month. The authors said physicians commonly see patients with this virus, but know little about it.

"It is important to understand the burden of disease caused by human metapneumovirus so that we can work on vaccines to prevent them. We want to understand the enemy so that we can counteract it," said Edwards.

MPV was first described in 2001 and there are no specific treatments or vaccines for it other than supportive care for bronchiolitis, such as oxygen, bronchodilators and intravenous fluids. No children involved in this study died from their infections. Williams said this is generally true for all the major causes of bronchiolitis in the United States because of the level of medical care available in this country.

"But in developing nations worldwide, lower respiratory illness is a leading cause of death in young children. Only diarrhea kills more children under the age of 5. We can infer, because of this study, that MPV is a major contributor to these deaths worldwide. We hope this will help stimulate more interest in research on vaccines and treatment for MPV," Williams said.

The major funding for this work came from the Centers for Disease Control and Prevention (CDC), with additional funding from the National Institutes of Health (NIH). Other Vanderbilt authors include Marie Griffin, M.D., MPH, professor of Preventive Medicine and Yuwei Zhu, M.D., M.S., senior associate in Biostatistics.


Story Source:

The above story is based on materials provided by Vanderbilt University Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kathryn M. Edwards, Yuwei Zhu, Marie R. Griffin, Geoffrey A. Weinberg, Caroline B. Hall, Peter G. Szilagyi, Mary A. Staat, Marika Iwane, Mila M. Prill, John V. Williams. Burden of Human Metapneumovirus Infection in Young Children. New England Journal of Medicine, 2013; 368 (7): 633 DOI: 10.1056/NEJMoa1204630

Cite This Page:

Vanderbilt University Medical Center. "Clues to childhood respiratory virus: Human metapneumovirus." ScienceDaily. ScienceDaily, 13 February 2013. <www.sciencedaily.com/releases/2013/02/130213173139.htm>.
Vanderbilt University Medical Center. (2013, February 13). Clues to childhood respiratory virus: Human metapneumovirus. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2013/02/130213173139.htm
Vanderbilt University Medical Center. "Clues to childhood respiratory virus: Human metapneumovirus." ScienceDaily. www.sciencedaily.com/releases/2013/02/130213173139.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins