Featured Research

from universities, journals, and other organizations

New method for researching understudied malaria-spreading mosquitoes

Date:
February 28, 2013
Source:
Johns Hopkins Bloomberg School of Public Health
Summary:
Researchers have developed a new method for studying the complex molecular workings of Anopheles albimanus, an important but less studied spreader of human malaria.

Researchers at the Johns Hopkins Malaria Research Institute have developed a new method for studying the complex molecular workings of Anopheles albimanus, an important but less studied spreader of human malaria. An. albimanus carries Plasmodium vivax, the primary cause of malaria in humans in South America and regions outside of Africa. Unlike Anopheles gambiae, the genome of the An. albimanus mosquito has not been sequenced and since these two species are evolutionarily divergent, the genome sequence of An. gambiae cannot serve as an appropriate reference.

The researcher's findings were published online in the journal Molecular & Cellular Proteomics.

"Technologies and platforms are needed to bridge the scientific gaps that could eventually spur the development of novel interventions to combat all human malaria," said study author, Rhoel Dinglasan, PhD, MPH, an assistant professor with the W. Harry Feinstone Department of Molecular Microbiology and Immunology at the Johns Hopkins Bloomberg School of Public Health. "To our knowledge, no approaches have been published that address this issue."

For the study, Dinglasan and his colleagues developed a method to compare proteins of the midgut of An. albimanus and An. gambiae. The mosquito midgut is a critical stage in the lifecycle of the malaria parasite and in the transmission of malaria to people. For An. albimanus, the researchers developed a seamless, integrated transcriptomic-to-proteomic approach involving assembly of the An. albimanus midgut transcriptome followed by acquisition of the luminal midgut microvilli proteome.

Dinglasan added, "This comparative proteomic analysis of the midgut brush borders of two important malaria vectors, An. gambiae and An. albimanus, which we envision will be one of many comparative studies, will help researchers develop new mosquito-based targets for drugs, vaccines or other interventions that would theoretically work in blocking both P. falciparum and P. vivax."

Malaria sickens more than 250 million people worldwide resulting in over 800,000 deaths, mostly African children.

"A Bioinformatics Approach for Integrated Transcriptomic and Proteomic Comparative Analyses of Model and Non-sequenced Anopheline Vectors of Human Malaria Parasites" was written by Ceereena Ubaida Mohien, David R. Colquhoun, Derrick K. Mathias, John G. Gibbons, Jennifer S. Armistead, Maria C. Rodriguez, Mario Henry Rodriguez, Nathan J. Edward, Jόrgen Hartler, Gerhard G. Thallinger, David R. Graham, Jesus Martinez-Barnetche, Antonis Rokas and Rhoel R. Dinglasan.

Funding for the researchers was provided by grants from the Bloomberg Family Foundation, the Johns Hopkins Malaria Research Institute and the National Heart, Lung and Blood Institute of the National Institutes of Health. (Grant# HHSN268201000032C).


Story Source:

The above story is based on materials provided by Johns Hopkins Bloomberg School of Public Health. Note: Materials may be edited for content and length.


Journal Reference:

  1. C. U. Mohien, D. R. Colquhoun, D. K. Mathias, J. G. Gibbons, J. S. Armistead, M. C. Rodriguez, M. H. Rodriguez, N. J. Edwards, J. Hartler, G. G. Thallinger, D. R. Graham, J. Martinez-Barnetche, A. Rokas, R. R. Dinglasan. A Bioinformatics Approach for Integrated Transcriptomic and Proteomic Comparative Analyses of Model and Non-sequenced Anopheline Vectors of Human Malaria Parasites. Molecular & Cellular Proteomics, 2012; 12 (1): 120 DOI: 10.1074/mcp.M112.019596

Cite This Page:

Johns Hopkins Bloomberg School of Public Health. "New method for researching understudied malaria-spreading mosquitoes." ScienceDaily. ScienceDaily, 28 February 2013. <www.sciencedaily.com/releases/2013/02/130228155442.htm>.
Johns Hopkins Bloomberg School of Public Health. (2013, February 28). New method for researching understudied malaria-spreading mosquitoes. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2013/02/130228155442.htm
Johns Hopkins Bloomberg School of Public Health. "New method for researching understudied malaria-spreading mosquitoes." ScienceDaily. www.sciencedaily.com/releases/2013/02/130228155442.htm (accessed September 18, 2014).

Share This



More Health & Medicine News

Thursday, September 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Artificial Sweetener Could Promote Diabetes

Artificial Sweetener Could Promote Diabetes

Newsy (Sep. 17, 2014) — Doctors once thought artificial sweeteners lacked the health risks of sugar, but a new study says they can impact blood sugar levels the same way. Video provided by Newsy
Powered by NewsLook.com
Ebola Vaccine Trial Gets Underway at Oxford University

Ebola Vaccine Trial Gets Underway at Oxford University

AFP (Sep. 17, 2014) — A healthy British volunteer is to become the first person to receive a new vaccine for the Ebola virus after US President Barack Obama called for action against the epidemic and warned it was "spiralling out of control." Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Obesity Rates Steady Even As Americans' Waistlines Expand

Obesity Rates Steady Even As Americans' Waistlines Expand

Newsy (Sep. 17, 2014) — Researchers are puzzled as to why obesity rates remain relatively stable as average waistlines continue to expand. Video provided by Newsy
Powered by NewsLook.com
President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) — President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins