Featured Research

from universities, journals, and other organizations

Metastasis: Understanding how cancer cells 'hijack' blood cells

Date:
March 5, 2013
Source:
Royal College of Surgeons in Ireland (RCSI)
Summary:
A new research study has investigated how cancer cells ‘hijack’ blood cells known as platelets and enable cancer to spread around the body to promote the growth of new tumors.

A new research study has investigated how cancer cells 'hijack' blood cells known as platelets, enabling cancer to spread around the body and promoting the growth of new tumours, it was reported today at the annual Royal College of Surgeons in Ireland (RCSI) Research Day.

The findings of this significant new study will inform the development of novel anti-cancer drugs.

Platelet blood cells normally have a role in blood clotting. In patients with cancer, cancer cells moving around in their bloodstream act on the platelets causing them to behave abnormally. The cancer cells encourage the platelets to clot around the cancer cell, protecting the cancer cell from the body's immune system and enabling the cancer to spread to other parts of the body.

Furthermore, the cancer cells cause the clusters of platelets to establish new blood vessels. This new blood source promotes the growth of secondary (metastatic) cancer tumours.

Explaining the significance of the study, senior author Professor Niamh Moran, Associate Professor in Molecular and Cellular therapeutics explained 'This is the first time that the exact molecular mechanisms at play between prostate cancer cells and platelets have been understood. It was already known that cancer patients with a higher platelet count had worse outcomes but we now know what causes this negative effect. Our study paves the way for the development of new anti-cancer treatments that may potentially prevent the spread of cancer.'

The first author on the study was PhD student Annachiara Mitrugno who worked in collaboration with Professor Moran and Professor David Williams, Associate Professor in Geriatric and Stroke Medicine, RCSI and Beaumont Hospital, who has a special interest in platelet research.

The research was funded by the Health Research Board (HRB) Scholars programme in Diagnostics and Therapeutics for Human Disease.

RCSI's annual Research Day provides scientists with the opportunity to showcase their most recent research findings. As one of Ireland's premier research institutions, exposure to world-class research begins at undergraduate level for the College's medical, pharmacy and physiotherapy students, right up to the highest-calibre research-active academic staff.


Story Source:

The above story is based on materials provided by Royal College of Surgeons in Ireland (RCSI). Note: Materials may be edited for content and length.


Cite This Page:

Royal College of Surgeons in Ireland (RCSI). "Metastasis: Understanding how cancer cells 'hijack' blood cells." ScienceDaily. ScienceDaily, 5 March 2013. <www.sciencedaily.com/releases/2013/03/130305130730.htm>.
Royal College of Surgeons in Ireland (RCSI). (2013, March 5). Metastasis: Understanding how cancer cells 'hijack' blood cells. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2013/03/130305130730.htm
Royal College of Surgeons in Ireland (RCSI). "Metastasis: Understanding how cancer cells 'hijack' blood cells." ScienceDaily. www.sciencedaily.com/releases/2013/03/130305130730.htm (accessed September 1, 2014).

Share This




More Health & Medicine News

Monday, September 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

Reuters - US Online Video (Aug. 30, 2014) California lawmakers pass a bill requiring universities to adopt "affirmative consent" language in their definitions of consensual sex, part of a nationwide drive to curb sexual assault on campuses. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
New Drug Could Reduce Cardiovascular Deaths

New Drug Could Reduce Cardiovascular Deaths

Newsy (Aug. 30, 2014) The new drug from Novartis could reduce cardiovascular deaths by 20 percent compared to other similar drugs. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins