Featured Research

from universities, journals, and other organizations

Detecting circulating tumor cells

Date:
March 25, 2013
Source:
American Institute of Physics
Summary:
A proof-of-concept device is nearly perfect in separating breast cancer cells from blood.

About 1 in 4 deaths in the United States are due to cancer, but primary tumors are rarely fatal. Instead, it's when tumors metastasize that cancer becomes so deadly. To help patients and physicians make treatment decisions, teams of researchers have been working on various methods to detect cancer's spread -- via the bloodstream -- before secondary tumors develop. Now, one team reports a nearly perfect method for separating breast cancer cells from blood. They describe their proof-of-concept device in a paper accepted for publication in Biomicrofluidics, a journal of the American Institute of Physics.

Detecting and separating circulating tumor cells (CTCs) is like finding the proverbial needle in a haystack: as few as one in a billion cells in a patient's bloodstream may be a CTC. Separation techniques vary widely, relying on differences in chemical, paramagnetic, or dielectric properties to distinguish CTCs from blood cells, or using mechanical sieves to cull the larger CTCs from the smaller blood cells. More recently, researchers have applied forces to fluid containing both blood cells and CTCs, using differences in inertia to sort cells. The technique, called "hydrodynamic sorting," is faster and easier than other sorting techniques. Like other mechanical techniques, it also allows researchers to collect viable cells after sorting them.

The team employed hydrodynamic sorting to develop their new device, called a multi-stage, multi-orifice flow fractionation (MS-MOFF) system. A previous design by the same team had just a single stage for applying hydrodynamic forces, but by adding an additional stage -- so the output of the first stage becomes the input to the second stage -- the researchers improved the separation efficiency of CTCs from 88.8% to 98.9%. Required pretreatment of the samples still makes MS-MOFF a proof-of-concept device, but the researchers suggest several ways to overcome such limitations and so make it useful for clinical applications.


Story Source:

The above story is based on materials provided by American Institute of Physics. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hui-Sung Moon, Kiho Kwon, Kyung-A Hyun, Tae Seok Sim, Jae Chan Park, Jeong-Gun Lee, Hyo-Il Jung. Continual collection and re-separation of circulating tumor cells from blood using multi-stage multi-orifice flow fractionation. Biomicrofluidics, 2013; 7 (1): 014105 DOI: 10.1063/1.4788914

Cite This Page:

American Institute of Physics. "Detecting circulating tumor cells." ScienceDaily. ScienceDaily, 25 March 2013. <www.sciencedaily.com/releases/2013/03/130325101537.htm>.
American Institute of Physics. (2013, March 25). Detecting circulating tumor cells. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2013/03/130325101537.htm
American Institute of Physics. "Detecting circulating tumor cells." ScienceDaily. www.sciencedaily.com/releases/2013/03/130325101537.htm (accessed April 24, 2014).

Share This



More Health & Medicine News

Thursday, April 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Fungus Killing Bats, Spreading in US

Deadly Fungus Killing Bats, Spreading in US

AP (Apr. 24, 2014) A disease that has killed more than six million cave-dwelling bats in the United States is on the move and wildlife biologists are worried. White Nose Syndrome, discovered in New York in 2006, has now spread to 25 states. (April 24) Video provided by AP
Powered by NewsLook.com
Companies Ramp Up Wellness to Lower Health Costs

Companies Ramp Up Wellness to Lower Health Costs

AP (Apr. 24, 2014) That little voice telling you to exercise, get in shape and get healthy is probably coming from your boss. More companies are beefing up wellness programs to try and cut down their health care costs. (April 24) Video provided by AP
Powered by NewsLook.com
Blood From World's Oldest Woman Suggests Life Limit

Blood From World's Oldest Woman Suggests Life Limit

Newsy (Apr. 24, 2014) Scientists say for the extremely elderly, their stem cells might reach a state of exhaustion. This could limit one's life span. Video provided by Newsy
Powered by NewsLook.com
FDA Wants To Ban Sales Of E-Cigarettes To Minors

FDA Wants To Ban Sales Of E-Cigarettes To Minors

Newsy (Apr. 24, 2014) The Food and Drug Administration wants to crack down on the use of e-cigarettes, banning the sale of the product to minors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins