Featured Research

from universities, journals, and other organizations

All water pills not equally effective against heart failure

Date:
April 1, 2013
Source:
Yale University
Summary:
Loop diuretics, more commonly known as water pills, are the most widely prescribed heart failure medications, but few studies had extensively compared their effectiveness until researchers examined three approved loop diuretics and found that even though one of them might offer more benefit, it is rarely prescribed.

Loop diuretics, more commonly known as water pills, are the most widely prescribed heart failure medications, but few studies had extensively compared their effectiveness until Yale School of Medicine researchers examined three approved loop diuretics and found that even though one of them might offer more benefit, it is rarely prescribed.

Published in the April 1 early edition of the Journal of the American College of Cardiology, the research compared the potential benefits of using one of three loop diuretics: toresemide, furosemide, and bumetanide.

"Loop diuretics are a cornerstone of heart failure treatment, so it is vital to understand the comparative effectiveness and real-world use of the drugs within this class," said lead author Dr. Behnood Bikdeli, postdoctoral associate in cardiovascular medicine at the Yale Center for Outcomes Research and Evaluation (CORE).

With over 5 million Americans suffering from heart failure, Bikdeli said that improving existing treatment options is key to providing the best care.

The team found that among 274,515 hospitalizations for heart failure during 2009 and 2010 across a large group of U.S. hospitals, 92% received loop diuretics during their hospital stay. Of those, 87% received furosemide as their only loop diuretic, 3% received bumetanide, and only 0.4% received torsemide, while 10% received a combination of these agents.

Although torsemide is slightly more expensive, the few available studies suggest that it lasts longer, is better tolerated, and might be associated with better clinical outcomes compared with the two other available water pills.

"There appears to be potential benefits from using torsemide compared with furosemide, but it is rarely used in practice," said Bikdeli. "Furosemide is the dominantly used loop diuretic in practice; however, if the potential advantages of torsemide over furosemide are proven in subsequent comparative effectiveness studies, this drug might become the preferred treatment of chronic heart failure."

Other authors on the study include Kelly Strait, Kumar Dharmarajan, Chohreh Partovian, Steven Coca, Nancy Kim, Shu-Xia Li, Jeffrey Testani, Usman Khan, and Harlan Krumholz.


Story Source:

The above story is based on materials provided by Yale University. The original article was written by Karen N. Peart. Note: Materials may be edited for content and length.


Journal Reference:

  1. Behnood Bikdeli, Kelly M. Strait, Kumar Dharmarajan, Chohreh Partovian, Steven G. Coca, Nancy Kim, Shu-Xia Li, Jeffrey M. Testani, Usman Khan, Harlan M. Krumholz. Dominance of Furosemide for Loop Diuretic Therapy in Heart Failure. Journal of the American College of Cardiology, 2013; 61 (14): 1549 DOI: 10.1016/j.jacc.2012.12.043

Cite This Page:

Yale University. "All water pills not equally effective against heart failure." ScienceDaily. ScienceDaily, 1 April 2013. <www.sciencedaily.com/releases/2013/04/130401161426.htm>.
Yale University. (2013, April 1). All water pills not equally effective against heart failure. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2013/04/130401161426.htm
Yale University. "All water pills not equally effective against heart failure." ScienceDaily. www.sciencedaily.com/releases/2013/04/130401161426.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
West Africa Gripped by Deadly Ebola Outbreak

West Africa Gripped by Deadly Ebola Outbreak

AFP (July 28, 2014) The worst-ever outbreak of the deadly Ebola epidemic grips west Africa, killing hundreds. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins