Featured Research

from universities, journals, and other organizations

Cells culled from adults may grow human bone

Date:
April 2, 2013
Source:
University of Michigan
Summary:
Preparations are underway for the first known human trial to use embryonic-like stem cells collected from adult cells to grow bone.

Dental work. Before extracting a tooth, U-M researchers harvest the patient's cells, and then NeoStem's VSEL technology is used to purify and isolate those VSEL stem cells from the patient's other cells.
Credit: Sergey / Fotolia

Preparations are underway for the first known human trial to use embryonic-like stem cells collected from adult cells to grow bone.

The cells technology, called VSEL stem cells, or very small embryonic-like stem cells, are derived from adults -- not fetuses. This eliminates ethical arguments and potential side effects associated with using actual embryonic stem cells derived from a fetus, say researchers at the University of Michigan School of Dentistry and New York-based NeoStem Inc.

The research partners hypothesize that the VSEL stem cells, which mimic properties of embryonic stem cells, can provide a minimally invasive way to speed painful bone regeneration for dental patients and others with bone trauma.

U-M's role in the study involves design, patient care and data analysis, while NeoStem provides the cells and patented technology to purify the special stem cells. Study leaders include Russell Taichman, U-M professor of dentistry; Laurie McCauley, professor and newly named dean of the U-M Dental School; and Denis Rodgerson, director of grants and academic liaisons for NeoStem. U-M's work will take place at the Michigan Center for Oral Health Research and the U-M Health System.

"Within a year, researchers hope to begin recruiting roughly 50 patients who need a tooth extraction and a dental implant," Taichman said.

Before extracting the tooth, U-M researchers harvest the patient's cells, and then NeoStem's VSEL technology is used to purify and isolate those VSEL stem cells from the patient's other cells.

This allows U-M researchers to implant pure populations of the VSEL stem cells back into test patients. Control patients receive their own cells, not the VSELs. After the new bone grows, researchers remove a small portion of it to analyze, and replace it with an implant.

"We're taking advantage of the time between extraction and implant to see if these cells will expedite healing time and produce better quality bone," Taichman said. "They are natural cells that are already in your body, but NeoStem's technology concentrates them so that we can place a higher quantity of them onto the wound site."

U-M has applied for initial patent protection to use the VSEL stem cells to grow bone. Robin Smith, chairman and CEO of NeoStem, emphasized the importance of this study for the development of embryonic-like stem cells from the patient's own body to treat a wide range of diseases.


Story Source:

The above story is based on materials provided by University of Michigan. Note: Materials may be edited for content and length.


Cite This Page:

University of Michigan. "Cells culled from adults may grow human bone." ScienceDaily. ScienceDaily, 2 April 2013. <www.sciencedaily.com/releases/2013/04/130402090826.htm>.
University of Michigan. (2013, April 2). Cells culled from adults may grow human bone. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2013/04/130402090826.htm
University of Michigan. "Cells culled from adults may grow human bone." ScienceDaily. www.sciencedaily.com/releases/2013/04/130402090826.htm (accessed October 2, 2014).

Share This



More Health & Medicine News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Might Not Be Out Of Control In U.S., But Coverage Is

Ebola Might Not Be Out Of Control In U.S., But Coverage Is

Newsy (Oct. 2, 2014) Coverage of the lone Ebola patient discovered in Texas has U.S. media in a frenzy — but does the coverage match the reality? Video provided by Newsy
Powered by NewsLook.com
US Hunts Contacts of Ebola Patient, Including Children

US Hunts Contacts of Ebola Patient, Including Children

AFP (Oct. 2, 2014) Health officials in Texas on Wednesday scoured the Dallas area for people, including schoolchildren, who came in contact with a Liberian man who was diagnosed with Ebola in the United States. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Study Says Losing Sense Of Smell Can Indicate Death

Study Says Losing Sense Of Smell Can Indicate Death

Newsy (Oct. 2, 2014) Researchers found elderly adults with a poor sense of smell are more likely to die within five years. Video provided by Newsy
Powered by NewsLook.com
Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins