Featured Research

from universities, journals, and other organizations

Cells culled from adults may grow human bone

Date:
April 2, 2013
Source:
University of Michigan
Summary:
Preparations are underway for the first known human trial to use embryonic-like stem cells collected from adult cells to grow bone.

Dental work. Before extracting a tooth, U-M researchers harvest the patient's cells, and then NeoStem's VSEL technology is used to purify and isolate those VSEL stem cells from the patient's other cells.
Credit: Sergey / Fotolia

Preparations are underway for the first known human trial to use embryonic-like stem cells collected from adult cells to grow bone.

Related Articles


The cells technology, called VSEL stem cells, or very small embryonic-like stem cells, are derived from adults -- not fetuses. This eliminates ethical arguments and potential side effects associated with using actual embryonic stem cells derived from a fetus, say researchers at the University of Michigan School of Dentistry and New York-based NeoStem Inc.

The research partners hypothesize that the VSEL stem cells, which mimic properties of embryonic stem cells, can provide a minimally invasive way to speed painful bone regeneration for dental patients and others with bone trauma.

U-M's role in the study involves design, patient care and data analysis, while NeoStem provides the cells and patented technology to purify the special stem cells. Study leaders include Russell Taichman, U-M professor of dentistry; Laurie McCauley, professor and newly named dean of the U-M Dental School; and Denis Rodgerson, director of grants and academic liaisons for NeoStem. U-M's work will take place at the Michigan Center for Oral Health Research and the U-M Health System.

"Within a year, researchers hope to begin recruiting roughly 50 patients who need a tooth extraction and a dental implant," Taichman said.

Before extracting the tooth, U-M researchers harvest the patient's cells, and then NeoStem's VSEL technology is used to purify and isolate those VSEL stem cells from the patient's other cells.

This allows U-M researchers to implant pure populations of the VSEL stem cells back into test patients. Control patients receive their own cells, not the VSELs. After the new bone grows, researchers remove a small portion of it to analyze, and replace it with an implant.

"We're taking advantage of the time between extraction and implant to see if these cells will expedite healing time and produce better quality bone," Taichman said. "They are natural cells that are already in your body, but NeoStem's technology concentrates them so that we can place a higher quantity of them onto the wound site."

U-M has applied for initial patent protection to use the VSEL stem cells to grow bone. Robin Smith, chairman and CEO of NeoStem, emphasized the importance of this study for the development of embryonic-like stem cells from the patient's own body to treat a wide range of diseases.


Story Source:

The above story is based on materials provided by University of Michigan. Note: Materials may be edited for content and length.


Cite This Page:

University of Michigan. "Cells culled from adults may grow human bone." ScienceDaily. ScienceDaily, 2 April 2013. <www.sciencedaily.com/releases/2013/04/130402090826.htm>.
University of Michigan. (2013, April 2). Cells culled from adults may grow human bone. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2013/04/130402090826.htm
University of Michigan. "Cells culled from adults may grow human bone." ScienceDaily. www.sciencedaily.com/releases/2013/04/130402090826.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins