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Liver cancers armed to evade immune response

Date:
April 17, 2013
Source:
Roswell Park Cancer Institute
Summary:
Researchers are studying highlights resilience of hepatocellular carcinomas, and are suggesting approaches for overcoming those barriers.

Researchers at Roswell Park Cancer Institute (RPCI) have published findings that help explain how a common and particularly resilient form of liver cancer evades the body's natural antitumor responses. The study, published April 15 in the journal Cancer Research, a publication of the American Association for Cancer Research (AACR), is the first to examine the combined effect of immunosuppression on immune function in advanced hepatocellular carcinoma (HCC), the fifth-most-common cancer in the world and the third-leading cause of cancer-related mortality globally.

In a study involving 23 patients with liver cancer, Yasmin Thanavala, PhD, a Professor of Oncology in the Department of Immunology, and colleagues measured multiple parameters of immune suppression simultaneously, revealing a previously undescribed picture of extreme immune dysfunction in patients with advanced HCC.

Therapeutic options for patients with inoperable HCC tumors are limited, the authors note. "Unfortunately, most patients with HCC are first diagnosed with the disease at an advanced stage or present with poor liver function," they write, "thereby preventing the use of potentially curative therapies." They concluded that the findings warrant further study in the clinical setting.

"We found that HCC patients accumulate an unusually high number and variety of immunosuppressive cells, which allows them to impede immunotherapies and facilitate tumor growth," says Dr. Thanavala, the study's senior author. "What we learned from this detailed analysis is that immunotherapies that have been shown to deplete these particular suppressor cells are likely to be effective in restoring immune function for HCC patients -- especially when combined with approaches that bolster the cancer-fighting T cells."

Co-authors are Suresh Kalathil, PhD, and Amit Lugade, PhD, from the Department of Immunology; Austin Miller, PhD, Assistant Professor of Oncology in the Department of Biostatistics & Bioinformatics; and Renuka Iyer, MD, Associate Professor of Oncology and Co-Director of the Liver and Pancreas Tumor Program.

This work was supported in part by the National Cancer Institute's Cancer Center Support Grant to RPCI (P30CA016056) and by funding from the American Cancer Society.


Story Source:

The above story is based on materials provided by Roswell Park Cancer Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. S. Kalathil, A. A. Lugade, A. Miller, R. Iyer, Y. Thanavala. Higher Frequencies of GARP CTLA-4 Foxp3 T Regulatory Cells and Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Are Associated with Impaired T-Cell Functionality. Cancer Research, 2013; 73 (8): 2435 DOI: 10.1158/0008-5472.CAN-12-3381

Cite This Page:

Roswell Park Cancer Institute. "Liver cancers armed to evade immune response." ScienceDaily. ScienceDaily, 17 April 2013. <www.sciencedaily.com/releases/2013/04/130417185528.htm>.
Roswell Park Cancer Institute. (2013, April 17). Liver cancers armed to evade immune response. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2013/04/130417185528.htm
Roswell Park Cancer Institute. "Liver cancers armed to evade immune response." ScienceDaily. www.sciencedaily.com/releases/2013/04/130417185528.htm (accessed August 1, 2014).

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