Featured Research

from universities, journals, and other organizations

Topical use of arthritis drug provides relief for dry eye disease, study suggests

Date:
April 18, 2013
Source:
Massachusetts Eye and Ear Infirmary
Summary:
An estimated nine million people in the United State alone suffer from significant dry eye disorder. Researchers have shown that topical anakinra (Kineret; Amgen Inc.), a recombinant version of human IL-1Ra approved for treatment of rheumatoid arthritis, significantly reduced dry eye symptoms.

Dry eye disease (DED) is a common condition that causes discomfort, visual disturbance and potentially damaging ocular surface inflammation that greatly impacts a person's quality of life. An estimated nine million people in the United State alone suffer from significant DED; millions more may have milder forms or experience discomfort when exposed to low humidity or contact lens use. DED, the most common reason people visit ophthalmologists, is estimated to cost $55 billion in annual direct and indirect costs to society in the nation alone.

In a new study, researchers from the Massachusetts Eye and Ear, Harvard Medical School, and Brigham and Women's hospital show that topical anakinra (Kineret; Amgen Inc.), a recombinant version of human IL-1Ra approved for treatment of rheumatoid arthritis, significantly reduced dry eye symptoms. Topical use of a protein-based biologic agent in treatment of DED is unprecedented and may herald a new era of highly targeted topical molecular treatments for ocular surface disease. The results of this clinical trial are described online first in JAMA Ophthalmology.

"We began looking at the possible therapeutic effects of IL-1Ra over 10 years ago in my laboratory," said Reza Dana, M.D., MSc., M.PH., senior author. "This clinical trial was a significant milestone in our research. The results clearly show us not only that we can possibly help the millions of people affected by dry eye disease worldwide, but that biologics such as this have the potential to provide targeted therapies for other ocular ailments, as well."

Early studies have shown that DED is associated with significant overexpression of inflammatory cytokines, including interleukin 1 (IL-1), in the eye. However the options to treat the inflammatory component of DED have been limited and some of these involved adverse effects. Anti-inflammatory medications such as tetracycline derivatives, topical corticosteroids, and cyclosporine A that have been successfully used in the treatment of DED downregulate the production of IL-1 and upregulate the production of IL-1 receptor antagonist (IL-1Ra) at the ocular surface. The IL-1Ra suppresses IL-1-mediated inflammation by completely inhibiting the binding of IL-1a and IL-1b to IL-1 receptor I. Topical IL-1Ra has been successfully used to treat experimental rodent models of corneal transplant rejection, dry eye disease, allergic conjunctivitis and alkali burn-associated ocular inflammation.

The researchers performed a randomized, double-masked clinical trial designed to assess the safety of efficacy of topical IL-1Ra in patients with DED. Seventy-five participants in the 16-week study were randomly allocated in the 2:2:1 ratio to receive eye lubricant (artificial tear), 2.5% of anakinra or 5% of anakinra. Patients found the anakinra was well tolerated and was significantly more effective than the eye lubricant in improving the signs and symptoms of DED. Anakinra at 2.5% was four times more likely than the eye lubricant to bilaterally eliminate corneal staining, a clinical measurement of ocular surface disease. Topical anakinra also significantly reduced dry eye symptoms six times more effectively than the eye lubricant, which is capable of independently improving the signs of DED. Moreover, termination of anakinra (but not the lubricant) application at week 12 lead to a clear trend toward increased symptoms between weeks 12 and 16, confirming the therapeutic effect of the drug.

"We have never seen results such as this before in a trial to treat dry eye disease. We possibly have found a safe, well tolerated eye drop that can treat the underlying cause of dry eye rather than just temporarily mask the symptoms. We are excited about the positive results we saw in the data and with our patients who found relief in their symptoms and were able to return to some of their normal daily activities," Dr. Dana said.


Story Source:

The above story is based on materials provided by Massachusetts Eye and Ear Infirmary. Note: Materials may be edited for content and length.


Journal Reference:

  1. Francisco Amparo et al. Topical Interleukin 1 Receptor Antagonist for Treatment of Dry Eye DiseaseA Randomized Clinical Trial. JAMA Ophthalmology, 2013 DOI: 10.1001/jamaophthalmol.2013.195

Cite This Page:

Massachusetts Eye and Ear Infirmary. "Topical use of arthritis drug provides relief for dry eye disease, study suggests." ScienceDaily. ScienceDaily, 18 April 2013. <www.sciencedaily.com/releases/2013/04/130418162310.htm>.
Massachusetts Eye and Ear Infirmary. (2013, April 18). Topical use of arthritis drug provides relief for dry eye disease, study suggests. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2013/04/130418162310.htm
Massachusetts Eye and Ear Infirmary. "Topical use of arthritis drug provides relief for dry eye disease, study suggests." ScienceDaily. www.sciencedaily.com/releases/2013/04/130418162310.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Microneedle Patch Promises Painless Pricks

Microneedle Patch Promises Painless Pricks

Reuters - Innovations Video Online (Oct. 18, 2014) Researchers at The National University of Singapore have invented a new microneedle patch that could offer a faster and less painful delivery of drugs such as insulin and painkillers. Video provided by Reuters
Powered by NewsLook.com
Raw: Nurse Nina Pham Arrives in Maryland

Raw: Nurse Nina Pham Arrives in Maryland

AP (Oct. 17, 2014) The first nurse to be diagnosed with Ebola at a Dallas hospital walked down the stairs of an executive jet into an ambulance at an airport in Frederick, Maryland, on Thursday. Pham will be treated at the National Institutes of Health. (Oct. 16) Video provided by AP
Powered by NewsLook.com
Raw: Cruise Ship Returns to US Over Ebola Fears

Raw: Cruise Ship Returns to US Over Ebola Fears

AP (Oct. 17, 2014) A Caribbean cruise ship carrying a Dallas health care worker who is being monitored for signs of the Ebola virus is heading back to Texas, US, after being refused permission to dock in Cozumel, Mexico. (Oct. 17) Video provided by AP
Powered by NewsLook.com
Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

AFP (Oct. 17, 2014) All four suspected Ebola cases admitted to hospitals in Spain on Thursday have tested negative for the deadly virus in a first round of tests, the government said Friday. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins