Featured Research

from universities, journals, and other organizations

Slow walking speed linked with premature death in kidney disease patients

Date:
April 18, 2013
Source:
American Society of Nephrology (ASN)
Summary:
Kidney disease patients who have slower walking speed on physical performance tests seem to be more burdened by their disease than patients who perform well on lower extremity physical performance tests, according to a new study. The findings indicate that measuring lower extremity physical performance may capture a complex set of skeletal muscle and neurologic impairments that develop in CKD patients and substantially affect their survival.

Kidney disease patients who have slower walking speed on physical performance tests seem to be more burdened by their disease than patients who perform well on lower extremity physical performance tests, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). The findings indicate that measuring lower extremity physical performance may capture a complex set of skeletal muscle and neurologic impairments that develop in CKD patients and substantially affect their survival.

Related Articles


Individuals with chronic kidney disease (CKD) have increased risks of becoming frail or disabled -- somewhat like the elderly -- and of dying from heart-related problems. Physical performance tests are often used to assess frailty and overall health in the elderly, but little is known about whether physical performance might be used to identify younger CKD patients at high risk of dying prematurely.

To study the issue, Baback Roshanravan, MD MS (Kidney Research Institute, Division of Nephrology at the University of Washington) and his colleagues followed 385 patients with CKD without a history of stroke or disability and with an average age of 61 years. The researchers compared handgrip strength, usual walking speed, six-minute walking distance, and timed up and go (the time that a person takes to rise from a chair, walk four meters, turn around, walk back to the chair, and sit down).

Among the major findings during the average three-year follow-up period: • Measures of lower extremity performance were at least 30% lower than predicted, but handgrip strength was relatively preserved. • Each 0.1-meter per second slower walking speed was linked with a 26% higher risk for death over an average three-year follow-up period, and each one-second longer timed up and go was linked with an 8% higher risk for death. • Walking speed and timed up and go more strongly predicted three-year mortality than kidney function or common blood tests. • Adding walking speed to common laboratory tests of kidney function significantly improved the prediction of three-year mortality.

The results indicate that impaired physical performance of the lower extremities is common in CKD and is strongly linked with premature death. "Our findings suggest that lower extremity physical performance testing in chronic kidney disease patients may help identify those individuals who are more burdened by their chronic kidney disease," said Dr. Roshanravan.

"Further studies will be necessary to examine the causal factors that are responsible for these findings," wrote Joel Kopple, MD (UCLA and the Los Angeles Biomedical Research Institute) in an accompanying editorial. "Given the current high interest in the problem of frailty in CKD patients, it can be anticipated that much new information," he added.

Study co-authors include Cassianne Robinson-Cohen, PhD, Kushang Patel, PhD, Ernest Ayers, Alyson Littman, PhD, Ian de Boer, MD, T. Alp Ikizler, MD, Jonathan Himmelfarb, MD, Leslie Katzel, MD, PhD, Bryan Kestenbaum, MD, and Stephen Seliger, MD.


Story Source:

The above story is based on materials provided by American Society of Nephrology (ASN). Note: Materials may be edited for content and length.


Journal Reference:

  1. Baback Roshanravan et al. Association between Physical Performance and All-Cause Mortality in CKD. Journal of the American Society of Nephrology, April 18, 2013 DOI: 10.1681/ASN.2012070702

Cite This Page:

American Society of Nephrology (ASN). "Slow walking speed linked with premature death in kidney disease patients." ScienceDaily. ScienceDaily, 18 April 2013. <www.sciencedaily.com/releases/2013/04/130418213925.htm>.
American Society of Nephrology (ASN). (2013, April 18). Slow walking speed linked with premature death in kidney disease patients. ScienceDaily. Retrieved November 21, 2014 from www.sciencedaily.com/releases/2013/04/130418213925.htm
American Society of Nephrology (ASN). "Slow walking speed linked with premature death in kidney disease patients." ScienceDaily. www.sciencedaily.com/releases/2013/04/130418213925.htm (accessed November 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com
Ebola: Life Without School in Guinea

Ebola: Life Without School in Guinea

AFP (Nov. 21, 2014) Following the closure of schools and universities in Guinea because of the Ebola virus, students look for temporary work or gather in makeshift classrooms to catch up on their syllabus. Duration: 02:14 Video provided by AFP
Powered by NewsLook.com
UN Says It Will Scale Up Its Ebola Response

UN Says It Will Scale Up Its Ebola Response

AFP (Nov. 20, 2014) UN Resident Coordinator David McLachlan-Karr and WHO representative in the country Daniel Kertesz updated the media on the UN Ebola response on Wednesday. Duration: 00:51 Video provided by AFP
Powered by NewsLook.com
Takata Offers "sincerest Condolences" To Victims of Malfunctioning Airbag

Takata Offers "sincerest Condolences" To Victims of Malfunctioning Airbag

Reuters - US Online Video (Nov. 20, 2014) U.S. Congress hears from a victim and company officials as it holds a hearing on the safety of Takata airbags after reports of injuries. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins