Featured Research

from universities, journals, and other organizations

Growing new arteries, bypassing blocked ones

Date:
April 29, 2013
Source:
Yale University
Summary:
Medical researchers have uncovered the molecular pathway by which new arteries may form after heart attacks, strokes and other acute illnesses bypassing arteries that are blocked.

Scientific collaborators from Yale School of Medicine and University College London (UCL) have uncovered the molecular pathway by which new arteries may form after heart attacks, strokes and other acute illnesses -- bypassing arteries that are blocked.

Related Articles


Their study appears in the April 29 issue of Developmental Cell.

Arteries form in utero and during development, but can also form in adults when organs become deprived of oxygen -- for example, after a heart attack. The organs release a molecular signal called VEGF. Working with mice, the Yale-UCL team discovered that in order for VEGF-driven artery formation to occur, VEGF must bind with two molecules known as VEGFR2 and NRP1, and all three must work as a team.

The researchers examined mice that were lacking a particular part of the NRP1 molecule that transports VEGF and VEGFR2 to a signaling center inside blood vessel walls. They observed that the internal organs of these mice contained poorly constructed arterial branches. Further, the mice where unable to efficiently repair blood vessel blockage through the formation of new arteries.

"We have identified an important new mechanism that regulates VEGFR2 transport in vascular cells," said corresponding author Michael Simons, professor of medicine and cell biology, and director of the cardiovascular research center at Yale School of Medicine. "This opens new therapeutic opportunities for developing drugs that would either stimulate or inhibit blood vessel formation -- important goals in cardiovascular and anti-cancer therapies, respectively." Simons also has an appointment as honorary professor of medicine at UCL.

The Yale-UCL collaboration began more than three years ago, as an intensive global effort to improve the human condition through biomedical research and translational medicine. The Yale-UCL alliance has provided many opportunities to date for high-level scientific research, and clinical and educational collaboration.

Co-senior author is Christiana Ruhrberg, professor of neuronal and vascular development at the Institute of Ophthalmology at University College London. Ruhrberg also has an appointment as adjunct professor of medicine at Yale School of Medicine.

Other authors are A. Lanahan, X. Zhang, Z.W. Zhuang, F. Rivera-Molina, C. Prahst, J. Zhang, Y. Wang, D. Toomre of Yale; A. Fantin of University College London, and K.R. Speichinger and G.E. Davis of the University of Missouri.

The study was supported by grants from the National Institutes of Health (HL62289) and a Wellcome Trust Junior Investigator award.


Story Source:

The above story is based on materials provided by Yale University. The original article was written by Helen Dodson. Note: Materials may be edited for content and length.


Journal Reference:

  1. Anthony Lanahan, Xi Zhang, Alessandro Fantin, Zhen Zhuang, Felix Rivera-Molina, Katherine Speichinger, Claudia Prahst, Jiasheng Zhang, Yingdi Wang, George Davis, Derek Toomre, Christiana Ruhrberg, Michael Simons. The Neuropilin 1 Cytoplasmic Domain Is Required for VEGF-A-Dependent Arteriogenesis. Developmental Cell, 2013; 25 (2): 156 DOI: 10.1016/j.devcel.2013.03.019

Cite This Page:

Yale University. "Growing new arteries, bypassing blocked ones." ScienceDaily. ScienceDaily, 29 April 2013. <www.sciencedaily.com/releases/2013/04/130429130508.htm>.
Yale University. (2013, April 29). Growing new arteries, bypassing blocked ones. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2013/04/130429130508.htm
Yale University. "Growing new arteries, bypassing blocked ones." ScienceDaily. www.sciencedaily.com/releases/2013/04/130429130508.htm (accessed October 31, 2014).

Share This



More Health & Medicine News

Friday, October 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Fauci Says Ebola Risk in US "essentially Zero"

Fauci Says Ebola Risk in US "essentially Zero"

AP (Oct. 30, 2014) NIAID Director Anthony Fauci said the risk of Ebola becoming an epidemic in the U.S. is essentially zero Thursday at the Washington Ideas Forum. He also said an Ebola vaccine will be tested in West Africa in the next few months. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Nurse Defies Ebola Quarantine With Bike Ride

Nurse Defies Ebola Quarantine With Bike Ride

AP (Oct. 30, 2014) A nurse who vowed to defy Maine's voluntary quarantine for health care workers who treated Ebola patients followed through on her promise Thursday, leaving her home for an hour-long bike ride. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Pot-Infused Edibles Raise Concerns in Colorado

Pot-Infused Edibles Raise Concerns in Colorado

AFP (Oct. 30, 2014) Colorado may have legalized marijuana for recreational use, but the debate around the decision still continues, with a recent - failed - attempt to ban cannabis-infused edibles. Duration: 01:53 Video provided by AFP
Powered by NewsLook.com
British Navy Ship Arrives in Sierra Leone With Ebola Aid

British Navy Ship Arrives in Sierra Leone With Ebola Aid

AFP (Oct. 30, 2014) The British ship RFA ARGUS arrived in Sierra Leone to deliver supplies and equipment to help the fight against Ebola. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins