Featured Research

from universities, journals, and other organizations

Dramatic decrease in risk of death for children on dialysis

Date:
May 8, 2013
Source:
McGill University Health Centre
Summary:
Children on dialysis for severe kidney disease have a dramatically reduced risk of death compared to 20 years ago, a new study shows. The findings are very encouraging for children with end-stage kidney disease. These children face a significantly shortened life expectancy, with dialysis as the only life-saving therapy while they await transplant.

Children on dialysis for severe kidney disease have a dramatically reduced risk of death compared to 20 years ago, a new study shows. The findings, from a study led by Dr. Bethany Foster from the Research Institute of the McGill University Health Centre (RI-MUHC), are very encouraging for children with end-stage kidney disease. These children face a significantly shortened life expectancy, with dialysis as the only life-saving therapy while they await transplant.

This study was published in The Journal of the American Medical Association (JAMA).

"This is important for children who need to spend longer periods of time on dialysis because they cannot receive a transplant or their transplantation failed," says Dr. Bethany Foster, corresponding author of the study and pediatric nephrologist at the Montreal Children's Hospital in Montreal. "Infants are one group that have to spend a longer time on dialysis because they have to grow -- usually to between one and two years of age before they can get a transplant."

Also known as end-stage renal disease (ESRD), this condition occurs when the kidneys are no longer able to perform at a level needed for day-to-day life. At that point, dialysis becomes a life-saving therapy while they await transplant. Unfortunately, children on dialysis with ESRD face a significant risk of death, up to 30 times higher than for healthy children, according to Dr. Foster.

"We wanted to see how outcomes have changed over time in children with ESRD who were citetreated with dialysis," explains Dr. Foster who is also an Associate Professor of Pediatrics at McGill University. Researchers analyzed an American database of more than 20,000 children who had received dialysis between 1990 and 2010. They found that the risk of death for children or adolescents being treated with dialysis has decreased dramatically, by about 20 per cent, over each five year period.

"Numerous factors may have contributed to the reduction in mortality risk over time such as improved pre-dialysis care, advances in dialysis technology, and greater experience of clinicians," says Dr. Foster. "Additional good news is that the period of time children spend on dialysis before transplant has also become shorter in recent years following changes in the way donated kidneys are allocated to children on the waiting list. Waiting times for children are substantially shorter than they used to be." A lower risk of death while being treated with dialysis, combined with a shorter time on dialysis adds up to a much brighter outlook for these children.

Further research is needed to determine the specific factors responsible for this decrease, but according to Dr. Foster and her colleagues, the results of this study are not only important for children who need dialysis, but also for their families, to help them understand that while dialysis is not a risk free undertaking, those risks have been dramatically decreased over time. As a result, these children are much more likely to be in good health when they arrive at the transplant phase.


Story Source:

The above story is based on materials provided by McGill University Health Centre. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mark M. Mitsnefes, Benjamin L. Laskin, Mourad Dahhou, Xun Zhang, Bethany J. Foster. Mortality Risk Among Children Initially Treated With Dialysis for End-Stage Kidney Disease, 1990-2010. JAMA, 2013;309(18):1921-1929 DOI: 10.1001/jama.2013.4208

Cite This Page:

McGill University Health Centre. "Dramatic decrease in risk of death for children on dialysis." ScienceDaily. ScienceDaily, 8 May 2013. <www.sciencedaily.com/releases/2013/05/130508131823.htm>.
McGill University Health Centre. (2013, May 8). Dramatic decrease in risk of death for children on dialysis. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2013/05/130508131823.htm
McGill University Health Centre. "Dramatic decrease in risk of death for children on dialysis." ScienceDaily. www.sciencedaily.com/releases/2013/05/130508131823.htm (accessed April 19, 2014).

Share This



More Health & Medicine News

Saturday, April 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins