Featured Research

from universities, journals, and other organizations

Heart failure accelerates male 'menopause'

Date:
May 25, 2013
Source:
European Society of Cardiology (ESC)
Summary:
Heart failure accelerates the aging process and brings on early andropausal syndrome (AS), according to new research. AS, also referred to as male 'menopause', was four times more common in men with heart failure.

Heart failure accelerates the aging process and brings on early andropausal syndrome (AS), according to research presented today at the Heart Failure Congress 2013. AS, also referred to as male 'menopause', was four times more common in men with heart failure.

The Heart Failure Congress is the main annual meeting of the Heart Failure Association of the European Society of Cardiology and is being held 25-28 May in Lisbon, Portugal (1).

As men get older they are more likely to suffer from andropausal syndrome (AS), also called 'menopause', androgen deficiency in the aging male (ADAM), or late-onset hypogonadism. Men with AS have decreased levels of anabolic hormones, including testosterone, and it has been suggested that these hormone deficiencies are what cause the clinical symptoms.

The symptoms of AS according to the Aging Male Symptom Rating Scale can be divided into three categories: sexual (erectile dysfunction, problems with libido, decrease in beard growth, feelings of 'having passed the zenith of life'), psychological (feeling discouraged, depressed, irritable, anxious, nervous), and somato-vegetative (joint and muscle complaints, sweating, need for more sleep, sleep disturbances, weakness, exhaustion).

Heart failure increases with age. Deficiencies of anabolic hormones are common in men with systolic heart failure, leading to reduced exercise capacity, depression and poor prognosis. But until now the impact of heart failure on the prevalence of AS and the severity of andropausal symptoms has not been studied.

Professor Ewa A. Jankowska (Wroclaw, Poland) said: "AS leads to poor quality of life. We wanted to discover whether heart failure increases AS and whether additional androgen therapies could improve quality of life in heart failure patients."

For the study (2), the researchers compared the prevalence of AS and the severity of andropausal symptoms between 232 men with systolic heart failure aged 40-80 years and 362 age-matched healthy peers. The magnitude of andropausal symptoms (psychological, sexual and somato-vegetative) was assessed using the Aging Males' Symptoms (AMS) Rating Scale and AS was diagnosed if the total AMS score was 50 points or more.

They found that AS affected almost one-third of men with heart failure, regardless of their age group. In men aged 40-59 years, heart failure led to a four-fold increase in the prevalence of AS (28% vs. 7%, p<0.001) and an increase in the severity of sexual and somato-vegetative andropausal symptoms (p<0.001). Men aged 60-80 years with and without heart failure had a similar prevalence of AS and severity of andropausal symptoms. Among men with systolic heart failure, the prevalence of AS was similar in both age groups (40-59 and 60-80 years).

The authors concluded that heart failure accelerates the natural process of aging and favours early onset of AS. Professor Jankowska said: "Heart failure leads to anabolic hormone deficiencies at a relatively young age and thereby accelerates male aging and the development of AS. These patients have poor quality of life and need endocrinological and sexual counselling."

It has been suggested that the anabolic hormone deficiencies in heart failure could be caused by heart failure treatments, which could affect the metabolism of hormones, or comorbidities, which might impair endocrine gland function. But in a second abstract (61271) the research group found few and weak associations between the presence of anabolic deficiencies, comorbidities and therapies in men with systolic heart failure. Professor Jankowska said: "This shows that it is the heart failure itself which impacts on the functioning of the endocrine glands."

She concluded: "Further research is needed to determine whether androgen supplementation can reduce the severity of andropausal symptoms."

References: 1. Heart Failure Congress 2013 http://www.escardio.org/congresses/hf2013/Pages/welcome.aspx?hit=nav 2. Thaczyszyn M, Nega K, Lopuszanska M, et al. Andropausal syndrome in men with systolic chronic heart failure, Presented at Heart Failure Congress 2013 Final Programme Number P640


Story Source:

The above story is based on materials provided by European Society of Cardiology (ESC). Note: Materials may be edited for content and length.


Cite This Page:

European Society of Cardiology (ESC). "Heart failure accelerates male 'menopause'." ScienceDaily. ScienceDaily, 25 May 2013. <www.sciencedaily.com/releases/2013/05/130525143826.htm>.
European Society of Cardiology (ESC). (2013, May 25). Heart failure accelerates male 'menopause'. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2013/05/130525143826.htm
European Society of Cardiology (ESC). "Heart failure accelerates male 'menopause'." ScienceDaily. www.sciencedaily.com/releases/2013/05/130525143826.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins