Medical researchers at the University of Alberta recently published their findings that rats with restricted growth in the womb, causing low birth weights when born, were most susceptible to developing age-related vision loss, compared to their normal weight counterparts. The research team members say additional work needs to be done to see if this same link exists in people, and if it does, doctors will need to better monitor vision concerns in adults who were born with a low birth weight.
"The consequence of our findings is that we are providing evidence for the need for clinicians to log birth weights of their patients when assessing health," says Yves Sauvé, the lead Faculty of Medicine & Dentistry researcher on the team.
"Most age-related eye diseases fall in the category of complex diseases, meaning that many factors can compound the severity of the risk, and birth weight could be one of those factors. Our finding points to the need to pursue more studies on the potential link between low birth weights at term and the risk of developing age-related vision losses."
Not only did the lab models have overall poorer vision as they aged, they specifically had poorer night vision, noted Sauvé and his colleagues. It is normal for night vision to be slightly affected with age, but night vision loss was worse as these lab models aged.
The team's findings were published in the peer-reviewed journal, Public Library of Science One (or PLOS One). Sauvé worked with his Faculty of Medicine & Dentistry colleagues Sandra Davidge and Stephane Bourque. Sauvé works in the Department of Physiology, the Department of Ophthalmology and the Centre for Neuroscience. Davidge is a professor in the Department of Obstetrics & Gynecology and the Department of Physiology, and is the director of the Women and Children's Health Research Institute. She is a Canada Research Chair in Women's Cardiovascular Health and an Alberta Innovates -- Health Solutions (AIHS)-funded Scientist.
Their research was funded by AIHS, the Canadian Institutes for Health Research, the Royal Alex Hospital Foundation, and the Stollery Children's Hospital Foundation.
The above story is based on materials provided by University of Alberta Faculty of Medicine & Dentistry. The original article was written by Raquel Maurier. Note: Materials may be edited for content and length.
- Stephane L. Bourque, Sharee Kuny, Laura M. Reyes, Sandra T. Davidge, Yves Sauv. Prenatal Hypoxia Is Associated with Long-Term Retinal Dysfunction in Rats. PLoS ONE, 2013; 8 (4): e61861 DOI: 10.1371/journal.pone.0061861
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