Featured Research

from universities, journals, and other organizations

Exposure to BPA in developing prostate increases risk of later cancer: Ubiquitous plasticizers may have long-term health effects

Date:
June 17, 2013
Source:
University of Illinois at Chicago
Summary:
Early exposure to BPA (bisphenol A) -- an additive commonly found in plastic water bottles and soup can liners -- causes an increased cancer risk in an animal model of human prostate cancer.

Early exposure to BPA (bisphenol A) -- an additive commonly found in plastic water bottles and soup can liners -- causes an increased cancer risk in an animal model of human prostate cancer, according to University of Illinois at Chicago researcher Gail Prins.

Prins presented her findings at the ENDO 2013 meeting in San Francisco June 17.

"This is the first direct evidence that exposure to BPA during development, at the levels we see in our day-to-day environment, increases the risk for prostate cancer in human prostate tissue," said Prins, professor of physiology and director of the andrology laboratory in urology at the UIC College of Medicine.

The increased risk can be traced to prostate stem and progenitor cells which become "sensitized" to estrogen early in development through exposure to BPA -- which mimics estrogen in the body. Environmental exposure to compounds like BPA that mimic hormones has become common, said Prins.

Prostate stem cells, which are very long-lived, pass on the increased estrogen sensitivity to the prostate tissues they produce throughout life. Because prostate cancer is fueled in part by naturally rising estrogen levels in aging men, the prostate tissue's increased sensitivity to estrogen makes the development of cancer much more likely, according to Prins.

"Studies of expectant mothers in the U.S. showed that more than 95 percent of them had BPA in their urine, which means they recently ingested these compounds, " says Prins, whose work led to banning the sale of baby bottles and cups containing BPA in Chicago in 2009.

Previous studies by Prins and colleagues using rats showed that exposure to elevated estrogen or BPA during embryonic development increased the rate of prostate cancer later in life. To determine if there was a link in humans, Prins developed a new animal model using human prostate stem cells implanted into mouse "hosts."

Prins took human prostate stem cells from deceased young adult male organ donors and implanted the cells into mice, where they formed human prostate tissue. To mimic exposure to BPA during early prostate development, Prins fed the mice BPA for the first two weeks after the transplant, at doses in line with those seen in pregnant American women. The tissue was then allowed to mature for a month into a human prostate-like tissue.

Next, Prins exposed the mice to elevated estrogen levels for two to four months, to mimic the normal rise in estrogen seen in aging men.

Signs of cancer developed in the human prostate tissue in a third of the mice fed BPA, as compared to only 12 percent in mice that had not been fed BPA. If the stem cells were exposed to BPA before implantation and again during development, 45 percent showed signs of cancer.

"We believe that BPA actually reprograms the stem cells to be more sensitive to estrogen throughout life, leading to a life-long increased susceptibility for diseases including cancer," Prins says.

W.Y. Hu, G.B. Shi, D.P. Hu, R.B. van Breeman and A. Kajdacsy-Balla, of UIC also contributed to the research.

This research was funded by grants from the National Institute of Environmental Sciences RC2 ES01878 (ARRA Award) and R01 ES015584.


Story Source:

The above story is based on materials provided by University of Illinois at Chicago. Note: Materials may be edited for content and length.


Cite This Page:

University of Illinois at Chicago. "Exposure to BPA in developing prostate increases risk of later cancer: Ubiquitous plasticizers may have long-term health effects." ScienceDaily. ScienceDaily, 17 June 2013. <www.sciencedaily.com/releases/2013/06/130617122133.htm>.
University of Illinois at Chicago. (2013, June 17). Exposure to BPA in developing prostate increases risk of later cancer: Ubiquitous plasticizers may have long-term health effects. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2013/06/130617122133.htm
University of Illinois at Chicago. "Exposure to BPA in developing prostate increases risk of later cancer: Ubiquitous plasticizers may have long-term health effects." ScienceDaily. www.sciencedaily.com/releases/2013/06/130617122133.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

More Coverage


Exposure to Low Doses of BPA Linked to Increased Risk of Prostate Cancer in Human Stem Cells

June 17, 2013 Exposing developing tissue to low levels of the plastic bisphenol A, commonly known as BPA, is linked to a greater incidence of prostate cancer in tissue grown from human prostate stem cells, a new ... read more
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins