Featured Research

from universities, journals, and other organizations

Testosterone therapy may help improve pain in men with low testosterone

Date:
June 17, 2013
Source:
Endocrine Society
Summary:
Testosterone therapy is associated with decreased pain perception in men with low testosterone levels related to opioid (narcotic) pain relievers (analgesics), a new study finds.

Testosterone therapy is associated with decreased pain perception in men with low testosterone levels related to opioid (narcotic) pain relievers (analgesics), a new study finds.

The results were presented Monday at The Endocrine Society's 95th Annual Meeting in San Francisco.

"In this study, we attempted to determine whether testosterone replacement improves pain perception and tolerance, and quality of life in men with low testosterone levels due to narcotic analgesics," said the study's lead author Shehzad Basaria, MD, Medical Director, Section of Men's Health, Aging, & Metabolism at Brigham & Women's Hospital, Harvard Medical School, in Boston, MA. "We found that testosterone administration in these men was associated with a greater reduction in several measures of pain sensitivity during laboratory pain testing compared with men who were on placebo."

Opioids belong to a class of pain-reducing drugs that are used to relieve chronic pain from injuries, surgery and cancer treatment. These drugs include morphine, codeine, fentanyl and oxycodone, and are among the most frequently prescribed medications in the United States today.

In addition to being highly addictive, opioid use is associated with a number of side effects, including suppression of the hypothalamic-pituitary-gonadal axis in both women and men, resulting in decreased testosterone production. Low testosterone, in turn, can result in sexual dysfunction, decreased muscle mass, increased fat mass and decreased quality of life.

Previous animal research has demonstrated that castration of rodents is associated with increased pain perception while testosterone replacement reduces pain perception, suggesting an analgesic effect of this sex steroid. Whether these beneficial effects can be replicated in humans, however, remained unclear.

In this study, investigators found that, compared to placebo, testosterone therapy significantly improved pain perception and tolerance during laboratory pain testing. Testosterone therapy also improved some aspects of quality of life.

"If larger studies confirm these findings, testosterone therapy in this patient population may be beneficial in improving pain perception," Basaria said.

The study included 84 men ages 18-64 years old with opioid-induced testosterone deficiency. Their average age was 49 years. Of this group, 65 participants completed the study. Investigators randomly assigned participants to receive either testosterone gel, applied to the skin, or placebo, for 14 weeks. Thirty-six men received the testosterone gel, and 29 received a placebo.

At the beginning of the study, and then again at 14 weeks, the investigators assessed pain measures and quality-of-life parameters.

Solvay (now Abbott) Pharmaceuticals, Inc. funded the study.


Story Source:

The above story is based on materials provided by Endocrine Society. Note: Materials may be edited for content and length.


Cite This Page:

Endocrine Society. "Testosterone therapy may help improve pain in men with low testosterone." ScienceDaily. ScienceDaily, 17 June 2013. <www.sciencedaily.com/releases/2013/06/130617142047.htm>.
Endocrine Society. (2013, June 17). Testosterone therapy may help improve pain in men with low testosterone. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2013/06/130617142047.htm
Endocrine Society. "Testosterone therapy may help improve pain in men with low testosterone." ScienceDaily. www.sciencedaily.com/releases/2013/06/130617142047.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com
Lost Brain Cells To Blame For Sleep Problems Among Seniors

Lost Brain Cells To Blame For Sleep Problems Among Seniors

Newsy (Aug. 21, 2014) According to a new study, elderly people might have trouble sleeping because of the loss of a certain group of neurons in the brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins