Featured Research

from universities, journals, and other organizations

One step closer to a vaccine for a common respiratory disease

Date:
June 17, 2013
Source:
Helsingin yliopisto (University of Helsinki)
Summary:
Young children and the elderly are especially susceptible to respiratory syncytial virus (RSV). The three-dimensional structure of respiratory syncytial virus has been solved by an international team from Finland and Switzerland.

Young children and the elderly are especially susceptible to respiratory syncytial virus (RSV). The three-dimensional structure of respiratory syncytial virus has been solved by an international team from Finland and Switzerland.
Credit: Image courtesy of Helsingin yliopisto (University of Helsinki)

Young children and the elderly are especially susceptible to respiratory syncytial virus (RSV). The three-dimensional structure of respiratory syncytial virus has been solved by an international team from Finland and Switzerland.

Related Articles


RSV is a common cause of respiratory infection, but there is no vaccine available. It causes flu-like symptoms in healthy adults, but becomes life-threatening in young children and the elderly. It is estimated to cause over 100,000 deaths yearly worldwide.

The teams of Research Director Sarah Butcher (Institute of Biotechnology, University of Helsinki) and Professor Ari Helenius (ETH Zurich) have now solved the three-dimensional structure of RSV.

"The structural model helps us to understand how infectious viruses are formed. This information can be useful in the intelligent design of vaccines" said the researcher Lassi Liljeroos.

RSV is related to measles and mumps viruses. All three viruses parasitize human cells, stealing parts of the cell membrane to use as their own. In RSV the resulting virus membranes look likes tubes and spheres. We could show that the virus' matrix protein controls this shape.

"In addition, we observed that the fusion protein on the surface is in two different forms. The fusion protein is responsible for attaching the virus to human cells and invading them. This is an important finding because the fusion protein is the key molecule in developing therapeutic antibodies to the virus. "

This publication is part of Lassi Liljeroos' Ph. D. thesis where he has earlier studied measles virus. The research was supported by the Academy of Finland, the Sigrid Juselius Foundation, the Viikki Molecular Biosciences Graduate Programme, the European Research Council, and the European Molecular Biology Organisation.


Story Source:

The above story is based on materials provided by Helsingin yliopisto (University of Helsinki). Note: Materials may be edited for content and length.


Journal Reference:

  1. Lassi Liljeroos, Magdalena Anna Krzyzaniak, Ari Helenius, Sarah Jane Butcher. Architecture of respiratory syncytial virus revealed by electron cryotomography. PNAS, 2013 DOI: 10.1073/pnas.1309070110

Cite This Page:

Helsingin yliopisto (University of Helsinki). "One step closer to a vaccine for a common respiratory disease." ScienceDaily. ScienceDaily, 17 June 2013. <www.sciencedaily.com/releases/2013/06/130617160750.htm>.
Helsingin yliopisto (University of Helsinki). (2013, June 17). One step closer to a vaccine for a common respiratory disease. ScienceDaily. Retrieved January 28, 2015 from www.sciencedaily.com/releases/2013/06/130617160750.htm
Helsingin yliopisto (University of Helsinki). "One step closer to a vaccine for a common respiratory disease." ScienceDaily. www.sciencedaily.com/releases/2013/06/130617160750.htm (accessed January 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, January 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Shark Bite Victim Making Amazing Recovery

Shark Bite Victim Making Amazing Recovery

AP (Jan. 27, 2015) A Texas woman who lost more than five pounds of flesh to a shark in the Bahamas earlier this month could be released from a Florida hospital soon. Experts believe she was bitten by a bull shark while snorkeling. (Jan. 27) Video provided by AP
Powered by NewsLook.com
Ebola Mistakes Should Serve a Lesson Says WHO

Ebola Mistakes Should Serve a Lesson Says WHO

AFP (Jan. 25, 2015) The World Health Organization&apos;s chief on Sunday admitted the UN agency had been caught napping on Ebola, saying it should serve a lesson to avoid similar mistakes in future. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins