Featured Research

from universities, journals, and other organizations

Antibiotics: Change route of delivery to mitigate resistance

Date:
June 26, 2013
Source:
American Society for Microbiology
Summary:
New research suggests that the rapid rise of antibiotic resistance correlates with oral ingestion of antibiotics, raising the possibility that other routes of administration could reduce the spread of resistance.

New research suggests that the rapid rise of antibiotic resistance correlates with oral ingestion of antibiotics, raising the possibility that other routes of administration could reduce the spread of resistance. The manuscript appears online ahead of print in the journal Antimicrobial Agents and Chemotherapy.

Related Articles


"For more than 40 years, a few doses of penicillin were enough to take care of deadly bacterial infections," says Hua Wang of the Ohio State University, Columbus, a researcher on the study. But since the 1980s, antibiotic resistance has been spreading rapidly, disabling once-powerful agents, leaving increasing numbers of patients to suffer, and even to die.

In earlier research, the investigators found a large cache of antibiotic resistance genes carried by nonpathogenic bacteria in many ready-to-consume food items. They also reported rapid development of resistant bacteria in infants who had not been exposed to antibiotics, shortly after birth, suggesting the gastrointestinal tract played a critical role in spreading resistance.

In the new research, the researchers inoculated lab mice with either Enterococcus species or Escherichia coli carrying specific resistance genes. The mice were then given tetracycline or ampicillin antibiotics, either orally, or via injection. Oral administration of antibiotics resulted in rapid rise of resistance genes as measured in the mice' feces. Resistance spread much less, and more slowly when the mice received antibiotics via injection.

The researchers also found that antibiotic resistance genes were not detectable in mice that had not been inoculated with bacteria containing antibiotic resistance genes, regardless of the route of antibiotic administration.

The human death toll from resistance, Wang says, is much higher than the 90,000 figure provided by the Centers for Disease Control and Prevention. The difference is due to the fact that bacterial infection is often the direct cause of death in many patients with chronic diseases, such as HIV/AIDS and cancer.

Besides resistance, recent work has shown that the use of oral antibiotics can reduce the diversity of the gut flora. Abnormalities of the gut flora are associated with multiple non-infectious diseases, including several autoimmune diseases and type II diabetes, according to Jeremy Nicholson of Imperial College, London, UK. Thus, alternatives to oral administration could likely mitigate these kinds of problems, as well.

Convenient alternatives to oral antibiotics might include transdermal administration via a patch, or other devices, says Wang.

Wang suggests that it should not be surprising that oral administration would abet the spread of resistance genes, since this route, unlike injection, directly exposes the humongous population of gastrointestinal bacteria to antibiotics. The resulting resistant microbes then get transmitted to the environment via the feces. From there, bacteria containing resistance genes once again gain entry to the food supply, via livestock, or via produce that has been exposed to manure from industrial livestock, as well as contaminated waste and soil, in a vicious cycle.

"Revealing this key risk factor is exciting because we have options other than oral administration, including convenient ones, for giving antibiotics," says Wang.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. L. Zhang, Y. Huang, Y. Zhou, T. Buckley, H. H. Wang. Antibiotic Administration Routes Significantly Influence the Levels of Antibiotic Resistance in Gut Microbiota. Antimicrobial Agents and Chemotherapy, 2013; DOI: 10.1128/AAC.00670-13

Cite This Page:

American Society for Microbiology. "Antibiotics: Change route of delivery to mitigate resistance." ScienceDaily. ScienceDaily, 26 June 2013. <www.sciencedaily.com/releases/2013/06/130626162818.htm>.
American Society for Microbiology. (2013, June 26). Antibiotics: Change route of delivery to mitigate resistance. ScienceDaily. Retrieved November 29, 2014 from www.sciencedaily.com/releases/2013/06/130626162818.htm
American Society for Microbiology. "Antibiotics: Change route of delivery to mitigate resistance." ScienceDaily. www.sciencedaily.com/releases/2013/06/130626162818.htm (accessed November 29, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, November 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rural India's Low-Cost Sanitary Pad Revolution

Rural India's Low-Cost Sanitary Pad Revolution

AFP (Nov. 28, 2014) — One man hopes his invention -– a machine that produces cheap sanitary pads –- will help empower Indian women. Duration: 01:51 Video provided by AFP
Powered by NewsLook.com
Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) — In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
WHO Says Male Ebola Survivors Should Abstain From Sex

WHO Says Male Ebola Survivors Should Abstain From Sex

Newsy (Nov. 28, 2014) — WHO cites four studies that say Ebola can still be detected in semen up to 82 days after the onset of symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins