Featured Research

from universities, journals, and other organizations

Higher genetic risk tied to lifetime asthma suffering

Date:
June 28, 2013
Source:
Duke University
Summary:
Children with more genetic risks for asthma are not only more likely to develop the condition at a young age, but they are also more likely to continue to suffer with asthma into adulthood. The finding is one of the latest to come from a 40-year longitudinal study of New Zealanders.

Children with more genetic risks for asthma are not only more likely to develop the condition at a young age, but they are also more likely to continue to suffer with asthma into adulthood. The finding reported by Duke University researchers is one of the latest to come from a 40-year longitudinal study of New Zealanders.

Related Articles


"We've been able to look at how newly discovered genetic risks relate to the life course of asthma at an unprecedented level of resolution," said Daniel Belsky, a postdoctoral fellow at the Duke Institute for Genome Sciences & Policy and the Center for the Study of Aging and Human Development.

Earlier studies had linked several genes to small increases in asthma risk. Belsky, along with Duke's Avshalom Caspi, Terrie Moffit and others, wanted to know whether those individual risks literally add up. They looked to the Dunedin Multidisciplinary Health and Development Study, an effort to examine the behavior and health -- including lung function -- of 1,037 individuals who have been tracked since their birth in Dunedin, New Zealand during a 12-month period from 1972-1973.

Belsky and his colleagues calculated a genetic risk score for each of 880 individuals in the Dunedin cohort by summing the number of risk variants each of them carried. They then asked whether those scores were related to the development and course of asthma from early childhood through midlife.

Indeed, they were. Those at higher genetic risk developed asthma earlier in life than did those with lower risk. Among the Dunedin study participants who developed asthma in childhood, those with higher genetic risk scores were also more likely to suffer with persistent asthma into adulthood. They more often had allergic reactions associated with severe and persistent asthma and developed problems with lung function.

Their quality of life suffered too, as those with higher genetic risk missed work and school more often and were more often admitted to the hospital because of asthma.

Belsky said there is still a long way to go before genetic risk scores like this one can be used in routine medical practice. In the meantime, the study could lead to a better understanding of the biology of asthma and advance research to devise new treatment and prevention strategies.

In the United States, 26 million people suffer from asthma, including more than 7 million children, according to the latest estimates from the Centers for Disease Control. Those numbers are growing every year at a cost of billions of dollars.

"It will be important to explore how these genetic risks play out in environments that differ in terms of air pollution or other important, modifiable factors," Belsky said.


Story Source:

The above story is based on materials provided by Duke University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Daniel W Belsky, Malcolm R Sears, Robert J Hancox, HonaLee Harrington, Renate Houts, Terrie E Moffitt, Karen Sugden, Benjamin Williams, Richie Poulton, Avshalom Caspi. Polygenic risk and the development and course of asthma: an analysis of data from a four-decade longitudinal study. The Lancet Respiratory Medicine, 2013; DOI: 10.1016/S2213-2600(13)70101-2

Cite This Page:

Duke University. "Higher genetic risk tied to lifetime asthma suffering." ScienceDaily. ScienceDaily, 28 June 2013. <www.sciencedaily.com/releases/2013/06/130628092151.htm>.
Duke University. (2013, June 28). Higher genetic risk tied to lifetime asthma suffering. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2013/06/130628092151.htm
Duke University. "Higher genetic risk tied to lifetime asthma suffering." ScienceDaily. www.sciencedaily.com/releases/2013/06/130628092151.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins