Featured Research

from universities, journals, and other organizations

Step forward in understanding arterial disease

Date:
July 16, 2013
Source:
University of Lincoln
Summary:
The next step has been made into isolating the origin of cells linked to the progressive disorder pulmonary arterial hypertension.

The next step has been made into isolating the origin of cells linked to the progressive disorder Pulmonary Arterial Hypertension.

Related Articles


Further strides have been made into isolating the origin of cells that could lead to a greater understanding of what goes into the development of our blood circulating systems.

University of Lincoln Life Sciences academic Dr Rajiv Machado, with colleagues from the University of Cambridge, King's College London and Papworth Hospital, has revealed the recent findings in a research letter to The American Journal of Respiratory and Critical Care Medicine.

Dr Machado's main research area is in Pulmonary Arterial Hypertension (PAH) which is a progressive disorder characterised by abnormally high blood pressure (hypertension) in the pulmonary artery, the blood vessel that carries blood from the heart to the lungs.

Symptoms are shortness of breath, dizziness, swelling (oedema) of the ankles or legs, chest pain and a racing pulse.

In this latest study, researchers investigated genetically identical twins, both of which had the genetic marker responsible for PAH.

However, only one had the disorder which resulted in both a heart and lung transplant.From this starting block, the team were able to investigate the origin of blood outgrowth endothelial cells (BOEC), which are stem cells and good candidates for vascular (re-) generating cell therapy. However, uncertainty remains as to the specific origin of these cells.

The researchers study of the twins and the mutation they both harboured enabled them to identify a marker to show that those stem cells, the BOECs, were very unlikely to have come from the heart or lungs.

Dr Machado said: "When the circulating BOECs were cultured from the new heart and lungs they still showed the mutation. Hence, they must have been produced in a different organ/s. The importance of this is that scientists are keen to know the origin of these cells both as a proxy for basic science and to provide an understanding of what goes into the development of our blood circulating systems. If we can in one fell swoop remove two organs as being contributory then we are another step closer to knowing where these cells come from."


Story Source:

The above story is based on materials provided by University of Lincoln. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jonas T. Sertório, Evandro M. Neto-Neves, Carlos A. Dias-Junior, Ozélia Sousa-Santos, Tamás Kiss, Diána Mühl, Jose E. Tanus-Santos. Elevated Plasma Hemoglobin Levels Increase Nitric Oxide Consumption in Experimental and Clinical Acute Pulmonary Thromboembolism*. Critical Care Medicine, 2013; 41 (7): e118 DOI: 10.1097/CCM.0b013e31827c0b43

Cite This Page:

University of Lincoln. "Step forward in understanding arterial disease." ScienceDaily. ScienceDaily, 16 July 2013. <www.sciencedaily.com/releases/2013/07/130716075543.htm>.
University of Lincoln. (2013, July 16). Step forward in understanding arterial disease. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2013/07/130716075543.htm
University of Lincoln. "Step forward in understanding arterial disease." ScienceDaily. www.sciencedaily.com/releases/2013/07/130716075543.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins