Featured Research

from universities, journals, and other organizations

Family history of diabetes increases the risk of prediabetes by 26 percent, with effect most evident in non-obese

Date:
August 22, 2013
Source:
Diabetologia
Summary:
A study involving more than 8,000 participants has shown that people with a family history of diabetes see their risk of prediabetes increase by 26 percent.

A study involving more than 8,000 participants has shown that people with a family history of diabetes see their risk of prediabetes increase by 26%. The research is published in Diabetologia, the journal of the European Association for the Study of Diabetes, and is by Dr Andreas Fritsche and colleagues from the German Center for Diabetes Research.

Related Articles


Prediabetes is a condition most often described as the 'state between normal blood sugar control and full diabetes', and indeed prediabetes progresses to full blown diabetes in up to 20% of individuals affected per year.

Prediabetes can take two forms: impaired fasting glycaemia (IFG), whereby levels of glucose in the fast state are higher than normal but not high enough to be classed as diabetes; and also impaired glucose tolerance (IGT), where blood sugar levels are abnormal due to increased insulin resistance. While it is known that a family history of type 2 diabetes increases the risk of full blown diabetes, research has not yet explored whether such a family history increases the risk of prediabetes in either form.

In this study Fritsche and colleagues analysed 8,106 non-diabetic individuals of European origin collected from the study centres of the German Center for Diabetes Research. Of these, 5,482 had normal glucose tolerance, and 2,624 had IFG and/or IGT n=2,624. They analysed whether having at least one first degree relative with diabetes is associated with prediabetes.

A family history of diabetes was found to increase the crude, unadjusted risk for prediabetes (IFG and/or IGT) by 40%. This increased risk fell to 26% when the analysis took account of age, sex, and BMI of participants.

When different types of prediabetes were considered, family history increased the risk of isolated IFG by 37%, of isolated IGT by 25%, and the two combined by 64%. However overall, when adjusted for BMI, the association between family history and prediabetes was seen only in non-obese individuals (BMI<30 kg/m2). The authors say: "Our data suggest that a family history of diabetes is associated with prediabetes in non-obese rather than in obese individuals. This might indicate the effect of family history on prediabetes becomes readily measurable only when not overshadowed by strong risk factors such as obesity."

They conclude: "We found that family history is an important risk factor for prediabetes, especially for combined IGT and IFG. Its relevance seems to be more evident in the non-obese."


Story Source:

The above story is based on materials provided by Diabetologia. Note: Materials may be edited for content and length.


Journal Reference:

  1. Robert Wagner et al. Family history of diabetes is associated with higher risk for prediabetes: a multicentre analysis from the German Center for Diabetes Research. Diabetologia, 2013 DOI: 10.1007/s00125-013-3002-1

Cite This Page:

Diabetologia. "Family history of diabetes increases the risk of prediabetes by 26 percent, with effect most evident in non-obese." ScienceDaily. ScienceDaily, 22 August 2013. <www.sciencedaily.com/releases/2013/08/130822091024.htm>.
Diabetologia. (2013, August 22). Family history of diabetes increases the risk of prediabetes by 26 percent, with effect most evident in non-obese. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2013/08/130822091024.htm
Diabetologia. "Family history of diabetes increases the risk of prediabetes by 26 percent, with effect most evident in non-obese." ScienceDaily. www.sciencedaily.com/releases/2013/08/130822091024.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins