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Single injection may revolutionize melanoma treatment

Date:
August 22, 2013
Source:
Moffitt Cancer Center
Summary:
A new study could offer hope to people with melanoma, the deadliest form of skin cancer. Researchers are investigating whether an injectable known as PV-10 can shrink tumors and reduce the spread of cancer. PV-10 is a solution developed from Rose Bengal, a water-soluble dye commonly used to stain damaged cells in the eye. Early clinical trials show PV-10 can boost immune response in melanoma tumors, as well as the blood stream.

A new study at Moffitt Cancer Center could offer hope to people with melanoma, the deadliest form of skin cancer. Researchers are investigating whether an injectable known as PV-10 can shrink tumors and reduce the spread of cancer. PV-10 is a solution developed from Rose Bengal, a water-soluble dye commonly used to stain damaged cells in the eye. Early clinical trials show PV-10 can boost immune response in melanoma tumors, as well as the blood stream.

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"Various injection therapies for melanoma have been examined over the past 40 years, but few have shown the promising results we are seeing with PV-10," said Shari Pilon-Thomas, Ph.D., assistant member of Moffitt's Immunology Program.

In the initial study, researchers injected a single dose of PV-10 into mice with melanoma. The result was a significant reduction in the skin cancer lesions, as well as a sizable reduction in melanoma tumors that had spread to the lungs. The researchers said the dye solution appeared to produce a robust anti-tumor immune response and may be safer than existing immunological agents.

"We are currently in the middle of our first human clinical trial of PV-10 for advanced melanoma patients. In addition to monitoring the response of injected melanoma tumors, we are also measuring the boost in the anti-tumor immune cells of patients after injection," explained Amod A. Sarnaik, M.D., assistant member of Moffitt's Cutaneous Oncology Program.

The initial study appears in PLOS ONE. It was supported by a sponsored research agreement with Provectus Pharmaceuticals, Inc., developer of PV-10.


Story Source:

The above story is based on materials provided by Moffitt Cancer Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Paul Toomey, Krithika Kodumudi, Amy Weber, Lisa Kuhn, Ellen Moore, Amod A. Sarnaik, Shari Pilon-Thomas. Intralesional Injection of Rose Bengal Induces a Systemic Tumor-Specific Immune Response in Murine Models of Melanoma and Breast Cancer. PLoS ONE, 2013; 8 (7): e68561 DOI: 10.1371/journal.pone.0068561

Cite This Page:

Moffitt Cancer Center. "Single injection may revolutionize melanoma treatment." ScienceDaily. ScienceDaily, 22 August 2013. <www.sciencedaily.com/releases/2013/08/130822194145.htm>.
Moffitt Cancer Center. (2013, August 22). Single injection may revolutionize melanoma treatment. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2013/08/130822194145.htm
Moffitt Cancer Center. "Single injection may revolutionize melanoma treatment." ScienceDaily. www.sciencedaily.com/releases/2013/08/130822194145.htm (accessed October 31, 2014).

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