Featured Research

from universities, journals, and other organizations

Scientific reproducibility is hampered by a lack of specificity of the material resources

Date:
September 5, 2013
Source:
PeerJ
Summary:
A key requirement when performing scientific experiments is the accessibility of material resources, including the reagents or model organisms, needed to address a specific hypothesis. The published scientific literature is a source of this valuable information, but frequently lacks sufficient detail to the extent that researchers are unable to identify material resources used to perform experiments.

A key requirement when performing scientific experiments is the accessibility of material resources, including the reagents or model organisms, needed to address a specific hypothesis. The published scientific literature is a source of this valuable information, but frequently lacks sufficient detail to the extent that researchers are unable to identify material resources used to perform experiments.

Related Articles


A study, published today in PeerJ, demonstrates the magnitude of the problem -- a problem that negatively affects the ability of scientists to reproduce and extend reported studies. The study showed that a large number of scientific resources are unidentifiable based on the information reported within the journal articles.

"The stories we tell in scientific publications are not necessarily instructions for replication." said Melissa Haendel, Ph.D., an ontologist and assistant professor in the Library and Department of Medical Informatics & Clinical Epidemiology at Oregon Health & Science University and senior author on the study. "This study illuminates how if we aim to use the literature as the scientific basis for reproducibility, then we have to get a lot more specific."

The study, led by Haendel and Nicole Vasilevsky, Ph.D., project manager and biocurator in Oregon Health & Science University's Ontology Development Group, examined nearly 240 articles from more than 80 journals spanning five disciplines: neuroscience, immunology, cell biology, developmental biology and general science. The articles were evaluated to determine if the reported research resources could be uniquely identified based on the information that was provided in each article, its supplemental data, or prior references. Specific criteria were developed to determine if antibodies, cell lines, constructs, model organisms, and knockdown reagents were identifiable. Based on these criteria, Haendel, Vasilevsky and their team of researchers also developed guidelines for reporting of research resources. These guidelines are available online (http://www.force11.org/node/4433) and can be used as a new data standard by authors, reviewers, publishers, and other data contributors to aid reproducibility.

The study showed that just under 50 percent of scientific resources used in previously published articles were unidentifiable, a percentage which varied across resource types and disciplines. The study also found no increased level of identification in journals that had more stringent reporting guidelines.

"We hope that quantifying the problem through this study will highlight to the research community that there is a significant and pressing need to make material resource information more accessible going forward," said Vasilevsky.


Story Source:

The above story is based on materials provided by PeerJ. Note: Materials may be edited for content and length.


Journal Reference:

  1. Nicole A. Vasilevsky, Matthew H. Brush, Holly Paddock, Laura Ponting, Shreejoy J. Tripathy, Gregory M. LaRocca, Melissa A. Haendel. On the reproducibility of science: unique identification of research resources in the biomedical literature. PeerJ, 2013; 1: e148 DOI: 10.7717/peerj.148

Cite This Page:

PeerJ. "Scientific reproducibility is hampered by a lack of specificity of the material resources." ScienceDaily. ScienceDaily, 5 September 2013. <www.sciencedaily.com/releases/2013/09/130905085904.htm>.
PeerJ. (2013, September 5). Scientific reproducibility is hampered by a lack of specificity of the material resources. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2013/09/130905085904.htm
PeerJ. "Scientific reproducibility is hampered by a lack of specificity of the material resources." ScienceDaily. www.sciencedaily.com/releases/2013/09/130905085904.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Science & Society News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Navy Unveils Robot Fish

Navy Unveils Robot Fish

Reuters - Light News Video Online (Dec. 18, 2014) — The U.S. Navy unveils an underwater device that mimics the movement of a fish. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) — As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
How 2014 Shaped The Future Of The Internet

How 2014 Shaped The Future Of The Internet

Newsy (Dec. 18, 2014) — It has been a long, busy year for Net Neutrality. The stage is set for an expected landmark FCC decision sometime in 2015. Video provided by Newsy
Powered by NewsLook.com
White House: Sony Hack a 'serious National Security Matter'

White House: Sony Hack a 'serious National Security Matter'

AFP (Dec. 18, 2014) — White House spokesperson Josh Earnest says cyber attacks that ultimately prompted Sony Pictures to scrap the release of a madcap comedy about North Korea are a "serious national security matter." Duration: 00:35 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Science & Society

Business & Industry

Education & Learning

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins