Featured Research

from universities, journals, and other organizations

Protein group affecting lipid dynamics at cell membranes discovered

Date:
September 23, 2013
Source:
Helsingin yliopisto (University of Helsinki)
Summary:
Eukaryotic cells are compartmentalized by membranes, whose shape and dynamics are precisely regulated to maintain their correct functions. Consequently, many cellular processes such as endocytosis, migration and morphogenesis rely on proteins that bind directly to membranes and sculpt them into desired shapes.

BAR proteins can create stable lipid microdomains at cell membranes.
Credit: Hongxia Zhao, hongxia.zhao@helsinki.fi

Eukaryotic cells are compartmentalized by membranes, whose shape and dynamics are precisely regulated to maintain their correct functions. Consequently, many cellular processes such as endocytosis, migration and morphogenesis rely on proteins that bind directly to membranes and sculpt them into desired shapes.

BAR domain proteins are among the central membrane-sculpting proteins in all eukaryote cells. Studies by Pekka Lappalainen laboratory at Institute of Biotechnology, University of Helsinki, Finland, now reveal that BAR domain proteins not only bend membranes, but also generate extremely stable lipid microdomains by inhibiting the lateral diffusion of certain lipids nearly completely.

In a new study published in Cell Reports, Hongxia Zhao working in the Lappalainen laboratory discovered that all BAR domain proteins induce strong clustering of phosphoinositides, which are important lipids involved in regulating protein functions and cellular signalling.

Her studies also revealed that BAR domains assemble into extremely stable scaffolds on the membrane. Surprisingly, mobility of phosphoinositides was nearly completely frozen in these BAR domain induced lipid platforms. These extremely stable protein-lipid scaffolds may contribute to diverse cellular processes by generating lipid phase boundaries at the tips of the BAR domain scaffolds. Furthermore, the membrane microdomains induced by BAR domains are expected to function as diffusion barriers, which may for example trap membrane-associated receptor and cargo molecules at the endocytic bud.

Thus, distribution and mobility of specific lipid species at the plasma membrane appears to precisely regulated by membrane-associated proteins. Hongxia Zhao is now continuing studies on regulation of lipid dynamics as an Academy Research Fellow at University of Helsinki.


Story Source:

The above story is based on materials provided by Helsingin yliopisto (University of Helsinki). Note: Materials may be edited for content and length.


Journal Reference:

  1. Hongxia Zhao, Alphιe Michelot, Essi V. Koskela, Vadym Tkach, Dimitrios Stamou, David G. Drubin, Pekka Lappalainen. Membrane-Sculpting BAR Domains Generate Stable Lipid Microdomains. Cell Reports, 2013; DOI: 10.1016/j.celrep.2013.08.024

Cite This Page:

Helsingin yliopisto (University of Helsinki). "Protein group affecting lipid dynamics at cell membranes discovered." ScienceDaily. ScienceDaily, 23 September 2013. <www.sciencedaily.com/releases/2013/09/130923092601.htm>.
Helsingin yliopisto (University of Helsinki). (2013, September 23). Protein group affecting lipid dynamics at cell membranes discovered. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2013/09/130923092601.htm
Helsingin yliopisto (University of Helsinki). "Protein group affecting lipid dynamics at cell membranes discovered." ScienceDaily. www.sciencedaily.com/releases/2013/09/130923092601.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) — In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) — The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) — President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) — A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins