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Surgical procedure examined in detecting cancer in lymph nodes near breast

Date:
October 7, 2013
Source:
American Medical Association (AMA)
Summary:
A study has been conducted to determine the false-negative rate of sentinel lymph node surgery in patients with node-positive breast cancer receiving chemotherapy before surgery.

Judy C. Boughey, M.D., Kelly K. Hunt, M.D., and colleagues for the Alliance for Clinical Trials in Oncology conducted a study to determine the false-negative rate of sentinel lymph node surgery in patients with node-positive breast cancer receiving chemotherapy before surgery. A false-negative is occurrence of negative test results in subjects known to have a disease for which an individual is being tested. The study, published by JAMA, is being released early online to coincide with its presentation at the American College of Surgeons 2013 Annual Clinical Congress.

Axillary (the armpit region) lymph node status is an important prognostic factor in breast cancer and is used to guide local, regional, and systemic treatment decisions. Accurate determination of axillary involvement after chemotherapy is important; however, removing all axillary nodes to assess for residual nodal disease exposes many patients to the potential side effects of surgery and, potentially, only a subset will benefit. To avoid the complications associated with axillary lymph node dissection (ALND), it is preferable to identify nodal disease with the less invasive sentinel lymph node (SLN) surgical procedure, which results in fewer side effects, according to background information in the article.

The American College of Surgeons Oncology Group (ACOSOG) Z1071 trial enrolled women from 136 institutions from July 2009 to June 2011 who had various stages of breast cancer and received neoadjuvant (before surgery) chemotherapy. Following chemotherapy, patients underwent both SLN surgery and ALND. The primary end point for the study was the false-negative rate of SLN surgery after chemotherapy in women who presented with cN1 disease (disease in movable axillary lymph nodes). The researchers evaluated the likelihood that the false-negative rate in patients with 2 or more SLNs examined was greater than 10 percent, the rate expected for women undergoing SLN surgery who present with clinical node-negative (cNO) disease.

Seven hundred fifty-six women were enrolled in the study. Of 663 evaluable patients with cN1 disease, 649 underwent chemotherapy followed by both SLN surgery and ALND. The researchers found that the false-negative rate was 12.6 percent with SLN surgery and exceeded the prespecified threshold of 10 percent. "Given this [10 percent] threshold, changes in approach and patient selection that result in greater sensitivity would be necessary to support the use of SLN surgery as an alternative to ALND in this patient population."


Story Source:

The above story is based on materials provided by American Medical Association (AMA). Note: Materials may be edited for content and length.


Journal Reference:

  1. Judy C. Boughey. Sentinel Lymph Node Surgery After Neoadjuvant Chemotherapy in Patients With Node-Positive Breast Cancer. JAMA, 2013; 310 (14): 1455 DOI: 10.1001/jama.2013.278932

Cite This Page:

American Medical Association (AMA). "Surgical procedure examined in detecting cancer in lymph nodes near breast." ScienceDaily. ScienceDaily, 7 October 2013. <www.sciencedaily.com/releases/2013/10/131007111945.htm>.
American Medical Association (AMA). (2013, October 7). Surgical procedure examined in detecting cancer in lymph nodes near breast. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2013/10/131007111945.htm
American Medical Association (AMA). "Surgical procedure examined in detecting cancer in lymph nodes near breast." ScienceDaily. www.sciencedaily.com/releases/2013/10/131007111945.htm (accessed July 28, 2014).

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