Featured Research

from universities, journals, and other organizations

Researchers close in on cause of gynecological disease

Date:
October 9, 2013
Source:
Michigan State University
Summary:
For the first time, researchers have created a model that could help unlock what causes adenomyosis, a common gynecological disease that is a major contributor to women having to undergo hysterectomies.

For the first time, researchers have created a model that could help unlock what causes adenomyosis, a common gynecological disease that is a major contributor to women having to undergo hysterectomies.

In a two-step process, a team led by Michigan State University's Jae-Wook Jeong first identified a protein known as beta-catenin that may play a key role in the development of the disease. When activated, beta-catenin causes changes in certain cells in a woman's uterus, leading to adenomyosis.

Then Jeong, an associate professor in the College of Human Medicine's Department of Obstetrics, Gynecology and Reproductive Biology, created a mouse model that may reveal useful targets for new treatments.

"Progress in the understanding what causes adenomyosis and finding potential drug treatments has been hampered by the lack of defined molecular mechanisms and animal models," Jeong said.

"These findings provide great insights into our understanding of the beta-catenin protein and will lead to the translation of animal models for the development of new therapeutic approaches."

The disease occurs when the inner lining of the uterus (endometrium) breaks through the muscle wall of the uterus (myometrium). Symptoms of the disease include menstrual bleeding, chronic pelvic pain and infertility. Most women with the disease require surgery, and 66 percent of hysterectomies are associated with it.

"This research offers hope to the millions of women who have adenomyosis and holds promise that a cure, besides hysterectomy, is on the horizon," said Richard Leach, chairperson of the Department of Obstetrics, Gynecology and Reproductive Biology.

The research results were recently published in the Journal of Pathology. The work was supported by grants from the National Institutes of Health, American Cancer Society and World Class University Program at Seoul National University in South Korea.

Leach added the study highlights the groundbreaking research being done in collaboration with other internationally renowned research centers in women's health.


Story Source:

The above story is based on materials provided by Michigan State University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Seo Jin Oh, Jung-Ho Shin, Tae Hoon Kim, Hee Sun Lee, Jung-Yoon Yoo, Ji Yeon Ahn, Russell R Broaddus, Makoto M Taketo, John P Lydon, Richard E Leach, Bruce A Lessey, Asgerally T Fazleabas, Jeong Mook Lim, Jae-Wook Jeong. β-Catenin activation contributes to the pathogenesis of adenomyosis through epithelial-mesenchymal transition. The Journal of Pathology, 2013; 231 (2): 210 DOI: 10.1002/path.4224

Cite This Page:

Michigan State University. "Researchers close in on cause of gynecological disease." ScienceDaily. ScienceDaily, 9 October 2013. <www.sciencedaily.com/releases/2013/10/131009130115.htm>.
Michigan State University. (2013, October 9). Researchers close in on cause of gynecological disease. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2013/10/131009130115.htm
Michigan State University. "Researchers close in on cause of gynecological disease." ScienceDaily. www.sciencedaily.com/releases/2013/10/131009130115.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins