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World first: Lungs awaiting transplant preserved 11 hours outside body

Date:
October 15, 2013
Source:
KU Leuven
Summary:
A multidisciplinary transplant team successfully preserved a set of donor lungs for over eleven hours with the help of a machine, the longest period ever reported. The lengthy preservation time was necessary because the patient needed a liver transplant immediately prior to the lung transplant. The patient has since left the hospital and is in good health.

The OCS LUNG™ machine continually flushes and oxygenates donor lungs at room temperature.
Credit: University Hospitals Leuven

The multidisciplinary transplant team at University Hospitals Leuven successfully preserved a set of donor lungs for over eleven hours with the help of a machine, the longest period ever reported. The lengthy preservation time was necessary because the patient needed a liver transplant immediately prior to the lung transplant. The patient has since left the hospital and is in good health.

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The patient, who suffered from chronic lung failure, developed sudden acute liver problems and went into a coma. The only surgical option for a patient with a terminal lung disease and a terminal liver disease is a combined lung and liver transplant.

But such double transplants pose a serious timing problem, says Dr. Dirk Van Raemdonck, who helped perform the surgery: "Normally, the lung transplant is carried out before the liver transplant. A donor lung typically can only be preserved outside the body for a maximum of ten hours. And a lung transplant can only be successful if the liver is still working properly. That is why we needed to transplant the liver before the lungs for this patient. To keep the donor lungs in good shape long enough after removal from the donor and prior to transplantation, our medical team used a new preservation technique."

The lungs were not put on ice as they usually are, but were preserved using a machine (OCS LUNG™) that provided continual flushing and oxygen at room temperature. Dr. Van Raemdonck: "The machine enabled us to keep the lungs outside the body for more than eleven hours with no negative effects, the longest period ever reported -- a world first."

World first

The new technique enables doctors to preserve lungs outside the body longer. The machine also provides an analysis of lung quality and can even improve lung function in anticipation of the transplant. A similar machine already exists for kidneys and results show that older kidneys preserved using that machine functioned better immediately after transplantation than kidneys preserved on ice did.

Currently, however, the new technique is not being reimbursed by insurance providers. The technique is being used only in special cases. Costs for this transplantation were covered entirely by University Hospitals Leuven and the maker of the machine.


Story Source:

The above story is based on materials provided by KU Leuven. Note: Materials may be edited for content and length.


Cite This Page:

KU Leuven. "World first: Lungs awaiting transplant preserved 11 hours outside body." ScienceDaily. ScienceDaily, 15 October 2013. <www.sciencedaily.com/releases/2013/10/131015094159.htm>.
KU Leuven. (2013, October 15). World first: Lungs awaiting transplant preserved 11 hours outside body. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2013/10/131015094159.htm
KU Leuven. "World first: Lungs awaiting transplant preserved 11 hours outside body." ScienceDaily. www.sciencedaily.com/releases/2013/10/131015094159.htm (accessed October 24, 2014).

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