Featured Research

from universities, journals, and other organizations

New drug reduces negative memory

Date:
October 21, 2013
Source:
University of Basel
Summary:
Through analysis of the human genome, scientists have identified molecules and compounds that are related to human memory. In a subsequent pharmacological study with one of the identified compounds, the scientists found a drug-induced reduction of aversive memory. This could have implications for the treatment of posttraumatic stress disorder, which is characterized by intrusive traumatic memories.

Genome-based identification of drugs.
Credit: University of Basel

Through analysis of the human genome, Basle scientists have identified molecules and compounds that are related to human memory. In a subsequent pharmacological study with one of the identified compounds, the scientists found a drug-induced reduction of aversive memory. This could have implications for the treatment of posttraumatic stress disorder, which is characterized by intrusive traumatic memories. The findings have been published in the latest edition of the magazine PNAS.

In the last decade, the human genome project has led to an unprecedented rate of discovery of genes related to humane disease. However, so far it has not been clear to what extent this knowledge can be used for the identification of new drugs, especially in the field of neuropsychiatric disorders. The research groups of Prof. Andreas Papassotiropoulos and Prof. Dominique de Quervain of the Psychiatric University Clinics, the Department of Psychology and the Biozentrum of the University of Basel performed a multinational collaborative study, in order to analyze the genetic basis of emotionally aversive memory -- a trait central to anxiety disorders such as posttraumatic stress disorder. In a gene-set analysis the scientists identified 20 potential drug target genes that are involved in the process of remembering negative events.

Known Antihistamine shows Effect

In a double-blind, placebo-controlled study and based on the results of the genetic analysis, the scientists examined a compound that interacts with one of the previously identified gene products. Surprisingly, the said compound is a known antihistamine. A single dose of the drug led to significant reduction of memory recall of previously seen aversive pictures; however, it did not affect memory of neutral or positive pictures. These findings could have implications for the treatment of posttraumatic stress disorder.

With this study, the scientists were for the first time able to demonstrate that human genome information can be used to identify substances that can modulate memory. "The rapid development of innovative methods for genetic analysis has made this new and promising approach possible," says Papassotiropoulos. The scientists are now planning subsequent studies: "In a further step, we will try to identify and develop memory enhancing drugs," explains de Quervain. The scientists hope to provide new input for the development of urgently needed improved drugs for the treatment of neuropsychiatric diseases.

Company for clinical Applications

In order to bring their findings to clinical application, de Quervain and Papassotiropulos founded the company GeneGuide Ltd. this year. The company has specialized in the human genome-based research approach and the discovery of new drugs for neuropsychiatric diseases. This novel approach has been met with great interest by the pharmaceutical industry, since so far the development of improved neuropsychiatric drugs has been rather disappointing.


Story Source:

The above story is based on materials provided by University of Basel. Note: Materials may be edited for content and length.


Journal Reference:

  1. Andreas Papassotiropoulos et al. Human genome–guided identification of memory-modulating drugs. PNAS, October 2013

Cite This Page:

University of Basel. "New drug reduces negative memory." ScienceDaily. ScienceDaily, 21 October 2013. <www.sciencedaily.com/releases/2013/10/131021153208.htm>.
University of Basel. (2013, October 21). New drug reduces negative memory. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2013/10/131021153208.htm
University of Basel. "New drug reduces negative memory." ScienceDaily. www.sciencedaily.com/releases/2013/10/131021153208.htm (accessed September 23, 2014).

Share This



More Mind & Brain News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Food Addiction Might Be Caused By PTSD

Food Addiction Might Be Caused By PTSD

Newsy (Sep. 18, 2014) New research shows that women who suffer from PTSD are three times more likely to develop a food addiction. Video provided by Newsy
Powered by NewsLook.com
Corporal Punishment on Decline, Debate Renews

Corporal Punishment on Decline, Debate Renews

AP (Sep. 16, 2014) Corporal punishment in the United States is on the decline, but there is renewed debate over its use after Minnesota Vikings running back Adrian Peterson was charged with child abuse. (Sept. 16) Video provided by AP
Powered by NewsLook.com
FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins