Featured Research

from universities, journals, and other organizations

Strategy to expand patient participation in hard-to-enroll clinical trials

Date:
October 23, 2013
Source:
University of Pennsylvania School of Medicine
Summary:
Clinical trials are key to finding new cancer treatments, but with patient participation hovering around 5 percent, new strategies are needed to boost enrollment, particularly to study the rare cancers that have so few cases.

Clinical trials are key to finding new cancer treatments, but with patient participation hovering around 5 percent, new strategies are needed to boost enrollment, particularly to study the rare cancers that have so few cases. One such strategy comes from a new abstract being presented October 28 at the 15th World Conference on Lung Cancer from researchers at Perelman School of Medicine at the University of Pennsylvania studying mesothelioma.

Results from a willingness to participate study, led by Charles B. Simone, MD, chief of Thoracic Oncology and assistant professor of Radiation Oncology at Penn's Abramson Cancer Center, found that focusing on particular factors -- including hope for positive outcomes, randomization and altruism -- and increasing the time spent with patients increased their likelihood of participating in a clinical trial for malignant pleural mesothelioma (MPM), a rare cancer often diagnosed in people who have been exposed to high levels of asbestos.

"Spending time with patients to thoroughly discuss the details, logistics, risks and benefits of enrollment can allow patients to have a better understanding of the proposed study, empower patients, and make them more likely to consider enrollment," said Dr. Simone. "Furthermore, identifying factors that may serve as obstacles to enrollment of a proposed study is critical and can help to tailor the discussion that researchers have with patients to address, substantiate, or alleviate their potential concerns."

The team, including Joseph S. Friedberg, MD, chief of the division of Thoracic Surgery and co-director of the Penn Mesothelioma and Pleural Disease Program, demonstrated unusually good results treating MPM with radical pleurectomy (RP), intraoperative photodynamic therapy (PDT), and chemotherapy. To establish if PDT is contributing to the results, a randomized trial of RP with and without PDT is needed. However, finding patients to enroll in such a trial is difficult. To see if they could conduct the trial, the researchers conducted the willingness to participate study.

Patients with MPM who were candidates for RP plus PDT were enrolled. A total of 25 patients participated in structured interviews, reviewed a written description of a hypothetical randomized controlled trial comparing RP to RP plus PDT, answered open-ended and focused questions regarding their motivations for and concerns about enrollment, and completed a written questionnaire. Willingness to participate was assessed using a 6-point scale: 1=definitely not, 6=definitely.

Once factors were identified in eight patients, researchers trained physicians to spend more time talking about these factors with subsequent patients, and the length of time physician spent discussing the trial increased from 3 minutes to 9 minutes. Such factors included hope for positive outcomes, explaining the randomization process, physician's opinion, and altruism towards other patients. Focusing on such factors in the latter group resulted in a more willingness to participate: 71 percent of subsequent patients stated they would "definitely" or "probably" participate, as opposed to only 25 percent in the first group.

"Performing a willingness to participate study should be considered before a planned prospective clinical trial, especially for orphan diseases and rare conditions that are typically associated with poor clinical trial accrual," said Dr. Simone.


Story Source:

The above story is based on materials provided by University of Pennsylvania School of Medicine. Note: Materials may be edited for content and length.


Cite This Page:

University of Pennsylvania School of Medicine. "Strategy to expand patient participation in hard-to-enroll clinical trials." ScienceDaily. ScienceDaily, 23 October 2013. <www.sciencedaily.com/releases/2013/10/131023165256.htm>.
University of Pennsylvania School of Medicine. (2013, October 23). Strategy to expand patient participation in hard-to-enroll clinical trials. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2013/10/131023165256.htm
University of Pennsylvania School of Medicine. "Strategy to expand patient participation in hard-to-enroll clinical trials." ScienceDaily. www.sciencedaily.com/releases/2013/10/131023165256.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins