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Ultrasound device combined with clot-buster safe for stroke

Date:
October 24, 2013
Source:
University of Texas Health Science Center at Houston
Summary:
A study showed that a hands-free ultrasound device combined with a clot-busting drug was safe for ischemic stroke patients.

Researchers at UTHealth in Houston are using Cerevast's CLOTBUST-ER device to see if ultrasound added to tPA can be beneficial for stroke patients. Results from an early study just published in the journal Stroke showed the device is safe.
Credit: Cerevast Therapeutics

A study led by researchers at The University of Texas Health Science Center at Houston (UTHealth) showed that a hands-free ultrasound device combined with a clot-busting drug was safe for ischemic stroke patients.

The results of the phase II pilot study were reported today in the American Heart Association journal Stroke. Lead author is Andrew D. Barreto, M.D., assistant professor of neurology in the Stroke Program at the UTHealth Medical School. Principal investigator is James C. Grotta, M.D., professor and chair of the Department of Neurology at the UTHealth Medical School, the Roy M. & Phyllis Gough Huffington Distinguished Chair and co-director of the Mischer Neuroscience Institute at Memorial Hermann-Texas Medical Center.

The device, which uses UTHealth technology licensed to Cerevast Therapeutics, Inc., is placed on the stroke patient's head and delivers ultrasound to enhance the effectiveness of the clot-busting drug tissue plasminogen activator (tPA). Unlike the traditional hand-held ultrasound probe that's aimed at a blood clot, the hands-free device used 18 separate probes and showers the deep areas of the brain where large blood clots cause severe strokes.

"Our goal is to open up more arteries in the brain and help stroke patients recover," said Barreto, an attending physician at Mischer Neuroscience Institute. "This technology would have a significant impact on patients, families and society if we could improve outcomes by another 10 percent or more by adding ultrasound to patients who've already received tPA."

In the first study of its kind, 20 moderately severe ischemic stroke patients (12 men and eight women, average age 63 years) received intravenous tPA up to 4.5 hours after symptoms occurred and two hours exposure to 2-MHz pulsed wave transcranial ultrasound.

Researchers reported that 13 (or 65 percent) patients either returned home or to rehabilitation 90 days after the combination treatment. After three months, five of the 20 patients had no disability from the stroke and one had slight disability.


Story Source:

The above story is based on materials provided by University of Texas Health Science Center at Houston. Note: Materials may be edited for content and length.


Journal Reference:

  1. Andrew D. Barreto et al. Prospective Validation of the Computed Tomographic Angiography Spot Sign Score for Intracerebral Hemorrhage. Stroke, October 2013 DOI: 10.1161/STROKEAHA.113.002713

Cite This Page:

University of Texas Health Science Center at Houston. "Ultrasound device combined with clot-buster safe for stroke." ScienceDaily. ScienceDaily, 24 October 2013. <www.sciencedaily.com/releases/2013/10/131024182431.htm>.
University of Texas Health Science Center at Houston. (2013, October 24). Ultrasound device combined with clot-buster safe for stroke. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2013/10/131024182431.htm
University of Texas Health Science Center at Houston. "Ultrasound device combined with clot-buster safe for stroke." ScienceDaily. www.sciencedaily.com/releases/2013/10/131024182431.htm (accessed August 21, 2014).

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