Featured Research

from universities, journals, and other organizations

New findings show damage resulting from lupus is a potentially modifiable outcome

Date:
October 27, 2013
Source:
American College of Rheumatology (ACR)
Summary:
Researchers have identified three potentially modifiable risk factors and one protective medication that may improve the health of people living with lupus.

According to research presented this week at the American College of Rheumatology Annual Meeting in San Diego, researchers have identified three potentially modifiable risk factors and one protective medication that may improve the health of people living with lupus.

Related Articles


Systemic lupus erythematosus, also called SLE or lupus, is a chronic inflammatory disease that can affect the skin, joints, kidneys, lungs, nervous system, and/or other organs of the body. The most common symptoms include skin rashes and arthritis, often accompanied by fatigue and fever. Lupus occurs mostly in women, typically developing in individuals in their twenties and thirties -- prime child- bearing age.

"Early tissue and organ damage in people with lupus can predict the likelihood of future damage and death due to the disease," says Ian N Bruce, MD, FRCP; professor of rheumatology at the University of Manchester, UK; current chair of the SLICC Inception Cohort; and lead investigator in the study. Dr. Bruce's team recently studied factors that might contribute to the development and progression of tissue and organ damage as well as the relationship between that damage and long-term survival rates. They found that increased disease activity, high blood pressure, and steroid use were associated with worsening damage, and the use of antimalarials protected against worsening damage from SLE.

Using the SLICC Inception Cohort Study -- which includes patients from 31 centers in 11 countries in North America, Europe, and Asia -- The SLICC group recruited 1,722 patients between 2000 and 2011 and enrolled them in the study within 15 months of meeting their fourth 1997 ACR criteria for having lupus. The average age of participants in the study was 35 years old and they averaged 4.25 follow-up visits throughout the duration of the study. All patients had a careful annual follow-up that included details of their lupus and its treatment as well as details other conditions they may have and other treatments they were taking.

1,502 patients -- including 1,337 females -- were analyzed for changes in the amount of irreversible damage they experienced over the study period. Damage was measured using the ACR/SLICC Damage Index (called SDI), which is an accepted standard measure of damage in SLE patients. Over the duration of the study, damage rates steadily increased so that by six years of follow-up, 51.1 percent had at least one item of damage recorded.

The researchers found that patients with initial damage were more likely to increase their SDI at each follow-up visit. They also found several factors that were associated with an increased risk of developing or increasing damage. These included older age, being of African ancestry within the USA, higher levels of inflammation (measured by the SLEDAI score), steroid use and high blood pressure.

They also found that men and Caucasians living in the United States were most likely to experience new damage and those who were from an Asian background had lower rates of new damage. In addition, taking antimalarial drugs reduced the rate of damage developing in patients with pre-existing damage. Finally, they found that each point increase in SDI score was associated with a moderate increased risk of death.

"This study shows that irreversible damage develops steadily over time in lupus patients and starts early in the course of the disease," says Dr. Bruce. "Many of the risk factors we have identified, such as high blood pressure, use of steroids and ongoing disease activity could potentially be modified. Clinical trials should test whether we can improve the long-term health of SLE patients by specifically targeting these risk factors in our patients."


Story Source:

The above story is based on materials provided by American College of Rheumatology (ACR). Note: Materials may be edited for content and length.


Cite This Page:

American College of Rheumatology (ACR). "New findings show damage resulting from lupus is a potentially modifiable outcome." ScienceDaily. ScienceDaily, 27 October 2013. <www.sciencedaily.com/releases/2013/10/131027123051.htm>.
American College of Rheumatology (ACR). (2013, October 27). New findings show damage resulting from lupus is a potentially modifiable outcome. ScienceDaily. Retrieved February 27, 2015 from www.sciencedaily.com/releases/2013/10/131027123051.htm
American College of Rheumatology (ACR). "New findings show damage resulting from lupus is a potentially modifiable outcome." ScienceDaily. www.sciencedaily.com/releases/2013/10/131027123051.htm (accessed February 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, February 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Cherries, Snap Peas and More Tasty Spring Produce

Cherries, Snap Peas and More Tasty Spring Produce

Buzz60 (Feb. 27, 2015) From sweet cherries to sugar snap peas, spring is the peak season for some of the tastiest and healthiest produce. Krystin Goodwin (@Krystingoodwin) has the best seasonal fruits and veggies to spring in to good health! Video provided by Buzz60
Powered by NewsLook.com
New FDA-Approved Diabetes Medicine Might Save Drugmaker

New FDA-Approved Diabetes Medicine Might Save Drugmaker

Newsy (Feb. 26, 2015) The U.S. Food and Drug Administration approved new diabetes drug Toujeo on Wednesday, a move that might save French drugmaker Sanofi&apos;s profits. Video provided by Newsy
Powered by NewsLook.com
The Best Foods to Battle Stress

The Best Foods to Battle Stress

Buzz60 (Feb. 26, 2015) If you&apos;re dealing with anxiety, there are a few foods that can help. Krystin Goodwin (@krystingoodwin) has the best foods to tame stress. Video provided by Buzz60
Powered by NewsLook.com
The 5 Best Tips to Look Younger Now

The 5 Best Tips to Look Younger Now

Buzz60 (Feb. 26, 2015) Life happens, and we all get older, but forget the pricey anti-aging products and plastic surgery. You can tweak your habits to turn back the hands of time. Krystin Goodwin (@krystingoodwin) has a few simple tips to help you look and feel younger. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins