Featured Research

from universities, journals, and other organizations

Brief exposure to performance-enhancing drugs may be permanently 'remembered' by muscles

Date:
October 27, 2013
Source:
Wiley
Summary:
Brief exposure to anabolic steroids may have long lasting, possibly permanent, performance-enhancing effects, shows a new study.

This shows muscle fibers with cell nuclei.
Credit: Jo C Bruusgaard

Brief exposure to anabolic steroids may have long lasting, possibly permanent, performance-enhancing effects, shows a study published today [28 October] in The Journal of Physiology.

Previously, re-acquisition of muscle mass -- with or without steroid use -- after periods of inactivity has been attributed to motor learning. However, this new data from the University of Oslo suggests that there is a cellular 'memory mechanism' within muscle of brief steroid users.

The team investigated the effects of steroids on muscle re-acquisition in mice and discovered greater muscle mass and more myonuclei -- which are essential components for muscle fibre function -- were apparent after returning to exercise.

Professor Kristian Gundersen explains how they carried out the study and the results found: "Mice were briefly exposed to steroids which resulted in increased muscle mass and number of cell nuclei in the muscle fibres. Three months after withdrawal of the drug (approximately 15% of a mouse's life span) their muscles grew by 30% over six days following load exercise. The untreated mice grew insignificantly."

The findings might have consequences for the exclusion time of doping offenders as brief exposure to anabolic steroids might have long lasting performance-enhancing effects.

Prof Gundersen says: "The results in our mice may correspond to the effects of steroids lasting for decades in humans given the same cellular 'muscle memory' mechanism. The new results might spur a debate on the current World Anti-Doping Agency (WADA) code in which the maximum exclusion time is currently two years."

Additionally, the data suggests that strength training when young might be beneficial later in life since the ability to generate new myonuclei is impaired in the elderly.

Future studies should include human muscles and further investigation into the cellular and molecular mechanism for muscle memory.


Story Source:

The above story is based on materials provided by Wiley. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ingrid M. Egner, Jo C Bruusgaard, Einar Eftestψl & Kristian Gundersen. A cellular memory mechanism aids overload hypertrophy in muscle long after an episodic exposure to anabolic steroids. Journal of Physiology, 2013

Cite This Page:

Wiley. "Brief exposure to performance-enhancing drugs may be permanently 'remembered' by muscles." ScienceDaily. ScienceDaily, 27 October 2013. <www.sciencedaily.com/releases/2013/10/131027205618.htm>.
Wiley. (2013, October 27). Brief exposure to performance-enhancing drugs may be permanently 'remembered' by muscles. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2013/10/131027205618.htm
Wiley. "Brief exposure to performance-enhancing drugs may be permanently 'remembered' by muscles." ScienceDaily. www.sciencedaily.com/releases/2013/10/131027205618.htm (accessed August 27, 2014).

Share This




More Mind & Brain News

Wednesday, August 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Stroke in Young Adults

Stroke in Young Adults

Ivanhoe (Aug. 27, 2014) — A stroke can happen at any time and affect anyone regardless of age. This mother chose to give her son independence and continue to live a normal life after he had a stroke at 18 years old. Video provided by Ivanhoe
Powered by NewsLook.com
Distracted Adults: ADHD?

Distracted Adults: ADHD?

Ivanhoe (Aug. 27, 2014) — Most people don’t realize that ADHD isn’t just for kids. It can affect the work as well as personal lives of many adults, and often times they don’t even know they have it. Video provided by Ivanhoe
Powered by NewsLook.com
The Sight and Sounds of Autism

The Sight and Sounds of Autism

Ivanhoe (Aug. 27, 2014) — A new study is explaining why for some people with autism what they see and what they hear is out of sync. Video provided by Ivanhoe
Powered by NewsLook.com
Bad Memories Turn Good In Weird Mouse Brain Study

Bad Memories Turn Good In Weird Mouse Brain Study

Newsy (Aug. 27, 2014) — MIT researchers were able to change whether bad memories in mice made them anxious by flicking an emotional switch in the brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins