Featured Research

from universities, journals, and other organizations

Houston we have a problem: Microgravity accelerates biological aging

Date:
October 31, 2013
Source:
Federation of American Societies for Experimental Biology
Summary:
As nations strive to put humans farther into space for longer periods of time, the real loser in this new space race could be the astronauts themselves. That's because experiments conducted on the International Space Station show that microgravity accelerates cardiovascular disease and the biological aging of these cells.

As nations strive to put humans farther into space for longer periods of time, the real loser in this new space race could be the astronauts themselves. That's because experiments conducted on the International Space Station involving cells that line the inner surfaces of blood vessels (endothelial cells) show that microgravity accelerates cardiovascular disease and the biological aging of these cells. These findings are presented in a new research report published in November 2013 issue of The FASEB Journal.

"Understanding the cellular and molecular events of senescence might help in finding preventive measures that are useful to improve the quality of life of millions of people," said Silvia Bradamante, a researcher involved in the work from the CNR-ISTM, Institute of Molecular Science and Technologies in Milan, Italy. "Our study further supports the role of oxidative stress in accelerating aging and disease."

In this report, Bradamante and colleagues examined endothelial cells in real microgravity aboard the International Space Station and conducted deep gene expression and protein analysis on the cells. They compared space-flown endothelial cells to endothelial cells cultured under normal gravity, looking for differences in gene expression and/or in the profile of secreted proteins. Space-flown cells differentially expressed more than 1,000 genes and secreted high amounts of pro-inflammatory cytokines. Ultimately, this induced significant oxidative stress, causing inflammation among endothelial cells, which in turn, led to atherosclerosis and cell senescence (biological aging).

"As we plan to send people deeper into space than ever before, and for longer flights, we've got to make sure that they remain in best health possible," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "We've evolved to rely on gravity to regulate our biology, and without it, our tissues become confused. Worst of all: they age faster!"


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. S. Versari, G. Longinotti, L. Barenghi, J. A. M. Maier, S. Bradamante. The challenging environment on board the International Space Station affects endothelial cell function by triggering oxidative stress through thioredoxin interacting protein overexpression: the ESA-SPHINX experiment. The FASEB Journal, 2013; 27 (11): 4466 DOI: 10.1096/fj.13-229195

Cite This Page:

Federation of American Societies for Experimental Biology. "Houston we have a problem: Microgravity accelerates biological aging." ScienceDaily. ScienceDaily, 31 October 2013. <www.sciencedaily.com/releases/2013/10/131031125317.htm>.
Federation of American Societies for Experimental Biology. (2013, October 31). Houston we have a problem: Microgravity accelerates biological aging. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2013/10/131031125317.htm
Federation of American Societies for Experimental Biology. "Houston we have a problem: Microgravity accelerates biological aging." ScienceDaily. www.sciencedaily.com/releases/2013/10/131031125317.htm (accessed July 23, 2014).

Share This




More Space & Time News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Raw: Cargo Craft Undocks from Space Station

Raw: Cargo Craft Undocks from Space Station

AP (July 22, 2014) A Russian Soyuz cargo-carrying spacecraft undocked from the International Space Station on Monday. The craft is due to undergo about ten days of engineering tests before it burns up in the Earth's atmosphere. (July 22) Video provided by AP
Powered by NewsLook.com
NASA Ceremony Honors Moon Walker Neil Armstrong

NASA Ceremony Honors Moon Walker Neil Armstrong

AP (July 21, 2014) NASA honored one of its most famous astronauts Monday by renaming a historic building at the Kennedy Space Center in Florida. It now bears the name of Neil Armstrong, the first man to walk on the moon. (July 21) Video provided by AP
Powered by NewsLook.com
Neil Armstrong's Post-Apollo 11 Life

Neil Armstrong's Post-Apollo 11 Life

Newsy (July 19, 2014) Neil Armstrong gained international fame after becoming the first man to walk on the moon in 1969. But what was his life like after the historic trip? Video provided by Newsy
Powered by NewsLook.com
This Week @ NASA, July 18, 2014

This Week @ NASA, July 18, 2014

NASA (July 18, 2014) Apollo 11 yesterday, Next Giant Leap tomorrow, Science instruments for Europa mission, and more... Video provided by NASA
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins