Featured Research

from universities, journals, and other organizations

Non-celiac wheat sensitivity: Is it an allergy?

Date:
November 5, 2013
Source:
American College of Gastroenterology (ACG)
Summary:
Patients with non-celiac wheat sensitivity and other food sensitivities showed clinical, laboratory and histological characteristics suggesting they may be suffering from a non-IgE-mediated food allergy, according to new research.

Patients with non-celiac wheat sensitivity (NCWS) and other food sensitivities showed clinical, laboratory and histological characteristics suggesting they may be suffering from a non-IgE-mediated food allergy, according to the article, "Non-Celiac Wheat Sensitivity as an Allergic Condition: Personal Experience and Narrative Review," published online today in The American Journal of Gastroenterology.

Related Articles


In this review, lead author Antonio Carroccio, M.D., from the University of Palermo in Palermo, Italy, examines prior data regarding NCWS and other relevant medical literature, focusing on NCWS patients who may suffer from non-IgE-mediated wheat allergy. Non-celiac wheat sensitivity (NCWS) is characterized by symptoms that can involve the gastrointestinal tract, the nervous system, the skin and other organs. The only common denominator of NCWS is wheat consumption: the symptoms disappear on exclusion of wheat from the diet, and reappear on wheat consumption.

Food allergies are typically divided into two areas: IgE mediated or non-IgE mediated. In IgE mediated food allergies, people develop symptoms almost immediately after eating, and when blood and skin tests are carried out, there is a positive marker. Non-IgE mediated food allergies, including celiac disease, primarily affect the GI mucosa (the innermost layer of the gastrointestinal tract) and have a delayed onset of symptoms, which can make it difficult to diagnosis.

Dr. Carroccio and his colleagues reviewed data on 276 patients diagnosed with NCWS using a double-blind placebo-controlled wheat challenge. The data indicating a possible wheat allergy diagnosis and other data in the literature were examined. The authors hypothesize that patients with NCWS may be suffering from non-IgE mediated food allergy.

"We reviewed the role of serum immunoglobulin G antibodies and the basophil activation assay in food allergy, as well as the histology findings in the food allergy diagnosis," said Dr. Carroccio. "We compared patients suffering from NCSW and irritable bowel syndrome (IBS) to controls with IBS not due to NCWS."

The review also suggests a link in wheat withdrawal and the intestinal microbiota. "A change in diet with wheat withdrawal can also cause a change in the intestinal microbiota. This is now considered a crucial element in IBS pathogenesis. Future studies in NCWS patients should consider the role of diet in the microbiota and, in turn, on the intestinal immune system," Dr. Carroccio added.

Based on his review, Dr. Carroccio concluded, "Non-celiac wheat sensitivity can now be considered the cause of gastrointestinal symptoms, which overlap those commonly attributed to functional disorders. However, many doubts remain and it must be underlined that we must utilize the double blind placebo-controlled challenge method to confirm the suspicion of non-celiac wheat sensitivity and then study the pathogenesis of that specific clinical manifestation. A confident NCWS diagnosis must exclude a placebo effect."


Story Source:

The above story is based on materials provided by American College of Gastroenterology (ACG). Note: Materials may be edited for content and length.


Journal Reference:

  1. Antonio Carroccio, Pasquale Mansueto, Alberto D'Alcamo, Giuseppe Iacono. Non-Celiac Wheat Sensitivity as an Allergic Condition: Personal Experience and Narrative Review. The American Journal of Gastroenterology, 2013; DOI: 10.1038/ajg.2013.353

Cite This Page:

American College of Gastroenterology (ACG). "Non-celiac wheat sensitivity: Is it an allergy?." ScienceDaily. ScienceDaily, 5 November 2013. <www.sciencedaily.com/releases/2013/11/131105081102.htm>.
American College of Gastroenterology (ACG). (2013, November 5). Non-celiac wheat sensitivity: Is it an allergy?. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2013/11/131105081102.htm
American College of Gastroenterology (ACG). "Non-celiac wheat sensitivity: Is it an allergy?." ScienceDaily. www.sciencedaily.com/releases/2013/11/131105081102.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins