Featured Research

from universities, journals, and other organizations

Osteoarthritis medicine delivered on-demand

Date:
November 6, 2013
Source:
American Chemical Society
Summary:
Scientists are reporting development of a squishy gel that when compressed -- like at a painful knee joint -- releases anti-inflammatory medicine. The new material could someday deliver medications when and where osteoarthritis patients need it most.

Scientists are reporting development of a squishy gel that when compressed -- like at a painful knee joint -- releases anti-inflammatory medicine. The new material could someday deliver medications when and where osteoarthritis patients need it most. Their study appears in the ACS journal Biomacromolecules.

Related Articles


Xinqiao Jia, Chandran R. Sabanayagam and colleagues note that in the past few decades, researchers have been developing a variety of "smart" hydrogels that can release medications over several days rather than in a single burst. Most of these gels release medicine all the time or in response to changes in temperature, light or other factors. Very few respond to physical pressure, which is what causes pain in the 27 million osteoarthritis patients in the U.S. Osteoarthritis is called the "wear-and-tear" type of arthritis. The cartilage between the bones becomes damaged and wears away, making everyday movements of the knees, hands, backs and hips severely painful. Jia and Sabanayagam set out to develop an on-demand, drug-delivery system for pain management and tissue repair in a way that makes more sense for osteoarthritis patients.

They created a special type of hydrogel that responds to compression -- such as the pressure between joints that occurs in everyday movement -- and loaded it with an anti-inflammatory drug called dexamethasone, which is sometimes used to treat arthritis. When they compressed the hydrogel in the laboratory, it boosted the release of the drug. The researchers are currently testing their smart pain medications in laboratory animals.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Longxi Xiao, Zhixiang Tong, Yingchao Chen, Darrin J. Pochan, Chandran R. Sabanayagam, Xinqiao Jia. Hyaluronic Acid-Based Hydrogels Containing Covalently Integrated Drug Depots: Implication for Controlling Inflammation in Mechanically Stressed Tissues. Biomacromolecules, 2013; 131023110629008 DOI: 10.1021/bm4011276

Cite This Page:

American Chemical Society. "Osteoarthritis medicine delivered on-demand." ScienceDaily. ScienceDaily, 6 November 2013. <www.sciencedaily.com/releases/2013/11/131106122119.htm>.
American Chemical Society. (2013, November 6). Osteoarthritis medicine delivered on-demand. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2013/11/131106122119.htm
American Chemical Society. "Osteoarthritis medicine delivered on-demand." ScienceDaily. www.sciencedaily.com/releases/2013/11/131106122119.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Hugging It Out Could Help You Ward Off A Cold

Hugging It Out Could Help You Ward Off A Cold

Newsy (Dec. 21, 2014) Carnegie Mellon researchers found frequent hugs can help people avoid stress-related illnesses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins