Featured Research

from universities, journals, and other organizations

Hope for transplant patients as study finds key to organ scarring

Date:
November 10, 2013
Source:
University of Edinburgh
Summary:
Patients with damaged organs could be helped by new treatments after scientists have discovered how tissues scar. Researchers say that the finding could pave the way for new drugs and eventually reduce the number of patients on organ transplant waiting lists.

Patients with damaged organs could be helped by new treatments after scientists have discovered how tissues scar. Researchers say that the finding could pave the way for new drugs and eventually reduce the number of patients on organ transplant waiting lists.

Related Articles


Fibrotic diseases occur in many tissues within the body -- including the liver, lung or kidneys -- and have a range of causes including viruses or toxins.

Scarring control

Experts say that the main source of scar tissue is found in specialised cells called myofibroblasts.

The study discovered that a molecule on these cells is a key regulator of fibrotic disease.

Scientists say that the molecule -- called alpha v integrin -- is a critical switch involved in turning on the myofibroblast cells to make scar tissue.

Regulating molecule

The team studied specially bred mice with fibrosis to see if removing the alpha v integrin molecule on myofibroblasts would reduce the amount of scar tissue in their organs.

Researchers found that when they removed alpha v integrin from these cells, the mice were protected from fibrosis of the liver, lung and kidneys.

They also found that when they treated the mice with a new experimental drug designed to block alpha v integrins, the animals were protected from liver and lung fibrosis.


Story Source:

The above story is based on materials provided by University of Edinburgh. Note: Materials may be edited for content and length.


Cite This Page:

University of Edinburgh. "Hope for transplant patients as study finds key to organ scarring." ScienceDaily. ScienceDaily, 10 November 2013. <www.sciencedaily.com/releases/2013/11/131110184408.htm>.
University of Edinburgh. (2013, November 10). Hope for transplant patients as study finds key to organ scarring. ScienceDaily. Retrieved April 19, 2015 from www.sciencedaily.com/releases/2013/11/131110184408.htm
University of Edinburgh. "Hope for transplant patients as study finds key to organ scarring." ScienceDaily. www.sciencedaily.com/releases/2013/11/131110184408.htm (accessed April 19, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, April 19, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Dr. Oz Under Fire For 'Quack Treatments' Yet Again

Dr. Oz Under Fire For 'Quack Treatments' Yet Again

Newsy (Apr. 17, 2015) Ten doctors signed a letter urging Columbia University to drop Dr. Oz as vice chair of its department of surgery, saying he plugs "quack" treatments. Video provided by Newsy
Powered by NewsLook.com
Scientists Find Link Between Gestational Diabetes And Autism

Scientists Find Link Between Gestational Diabetes And Autism

Newsy (Apr. 17, 2015) Researchers who analyzed data from over 300,000 kids and their mothers say they&apos;ve found a link between gestational diabetes and autism. Video provided by Newsy
Powered by NewsLook.com
Video Messages Help Reassure Dementia Patients

Video Messages Help Reassure Dementia Patients

AP (Apr. 17, 2015) Family members are prerecording messages as part of a unique pilot program at the Hebrew Home in New York. The videos are trying to help victims of Alzheimer&apos;s disease and other forms of dementia break through the morning fog of forgetfulness. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins