Featured Research

from universities, journals, and other organizations

Study unveils potential of re-activating tumor fighting proteins within cell

Date:
November 15, 2013
Source:
European Association of Urology
Summary:
New study suggests that selective blockade of CRM1-dependent nuclear export represents a completely novel, tumor metastasis-selective approach for the treatment of advanced metastatic prostate cancers.

New study suggests that selective blockade of CRM1-dependent nuclear export represents a completely novel, tumor metastasis-selective approach for the treatment of advanced metastatic prostate cancers.

Related Articles


According to the researchers, the human nuclear export protein chromosomal region maintenance/exportin 1/Xpo1 (CRM1) is the sole exportin mediating transport of many multiple tumor suppressor proteins out of the nucleus. Their study aimed to verify the hypothesis that CRM1 inhibition could be beneficial for the treatment of prostate cancer metastases, which was achieved by testing the effects of the orally available, potent and selective, clinical stage SINE compound KPT 330.

"Although the class of compounds used in our studies -- SINEs or Selective Inhibitors of Nuclear Export -- have just recently entered early clinical testing, our results suggest that these agents could be active in patients with androgen-independent prostate cancer," commented study's lead author Dr. Claudio Festuccia, of the University of L'Aquila in Italy.

"Most of the current treatments for prostate cancer work by reducing the levels or blocking the receptors for a set of hormones called androgens. These SINE compounds act through an entirely new mechanism by re-activating a cells own tumor fighting proteins. These tumor fighting proteins, called tumor suppressor proteins, act as a guardian against the development of cancers by detecting damage to a cell's DNA and if DNA damage is found, activating the cell's own suicide program," he explained.

"Since all cancers have a great deal of DNA damage, re-activation of tumor suppressor proteins could cause the cancer to commit suicide. We observed just such an effect with these new SINE drug candidates."

According to the authors, the study also showed that these new SINE drug candidates prevented prostate cancer cells from causing damage to bones.

"The mechanisms of preventing the damage are now being worked out, but it appears that these new SINE drug candidates can suppress a type of bone cell called an osteoclast," said Festuccia.

Osteoclasts are activated by prostate cancer cells to destroy bone, and play an important role in prostate cancer-associated bone disease.

The results of this study will be presented at the 5th European Multidisciplinary Meeting on Urological Cancers in Marseille, France, on 15-17 November 2013.


Story Source:

The above story is based on materials provided by European Association of Urology. Note: Materials may be edited for content and length.


Cite This Page:

European Association of Urology. "Study unveils potential of re-activating tumor fighting proteins within cell." ScienceDaily. ScienceDaily, 15 November 2013. <www.sciencedaily.com/releases/2013/11/131115094319.htm>.
European Association of Urology. (2013, November 15). Study unveils potential of re-activating tumor fighting proteins within cell. ScienceDaily. Retrieved January 25, 2015 from www.sciencedaily.com/releases/2013/11/131115094319.htm
European Association of Urology. "Study unveils potential of re-activating tumor fighting proteins within cell." ScienceDaily. www.sciencedaily.com/releases/2013/11/131115094319.htm (accessed January 25, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, January 25, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com
This Is What It's Like To Date A Med Student

This Is What It's Like To Date A Med Student

BuzzFeed (Jan. 23, 2015) Dating is now speed-dating... or studying. Video provided by BuzzFeed
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins