Featured Research

from universities, journals, and other organizations

Probe measuring immune function can be used to determine nanoparticle dosage for patients

Date:
November 20, 2013
Source:
University of North Carolina School of Medicine
Summary:
The development of a probe to measure the body’s immune function could lead to more accurate, individualized doses for cancer patients prescribed nanoparticle-based drugs, according to research.

The development of a probe to measure the body’s immune function could lead to more accurate, individualized doses for cancer patients prescribed nanoparticle-based drugs, according to research conducted at the University of North Carolina.

Nanoparticles – drugs encapsulated in carriers measured at the scale of a one billionth of a meter – were developed as a method to deliver more chemotherapy to to specific tumor sites within the body. One major downside of this class of drugs is that the ability of a patient bto remove the drug from the body can vary widely from patient to patient and thus lead to variability in response.

In a paper published online by the Journal of Pharmacology and Experimental Therapeutics , William Zamboni, PharmD, PhD, associate professor in the UNC Eshelman School of Pharmacy and member of the UNC Lineberger Comprehensive Cancer Center, in collaboration with Paola Gehrig, MD, and colleagues in UNC Gynecologic Oncology Program, outlines how a UNC-developed probe that measures the function of the mononuclear phagocyte system (MPS) can help determine the proper dosage of nanoparticle-based drugs to administer to patients.

Using a blood sample, researchers were able to use a chemical probe and method developed at UNC to track a direct relationship between MPS function and clearance of the nanodrug pegylated liposomal doxorubicin (Doxil®) in both animal models and in patients with ovarian cancer.

“You could use this probe to individualize the dose of nanoparticle agent that a patient should be administered,” said Zamboni.

While most conventional drugs are cleared from the body by the liver and kidneys, nanoparticles are engulfed and cleared by the monocytes, macrophages and dendritic cells that make up the MPS. Because the function of the MPS is highly variable across patients, the ability of physicians to predict the proper dosage for nanodrugs is more difficult than with conventional pharmaceuticals.

“The more active the MPS system, the faster these drugs are cleared from a patient,” said Zamboni.


Story Source:

The above story is based on materials provided by University of North Carolina School of Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. W. P. Caron, J. C. Lay, A. M. Fong, N. M. La-Beck, P. Kumar, S. E. Newman, H. Zhou, J. H. Monaco, D. L. Clarke-Pearson, W. R. Brewster, L. Van Le, V. L. Bae-Jump, P. A. Gehrig, W. C. Zamboni. Translational Studies of Phenotypic Probes for the Mononuclear Phagocyte System and Liposomal Pharmacology. Journal of Pharmacology and Experimental Therapeutics, 2013; 347 (3): 599 DOI: 10.1124/jpet.113.208801

Cite This Page:

University of North Carolina School of Medicine. "Probe measuring immune function can be used to determine nanoparticle dosage for patients." ScienceDaily. ScienceDaily, 20 November 2013. <www.sciencedaily.com/releases/2013/11/131120100311.htm>.
University of North Carolina School of Medicine. (2013, November 20). Probe measuring immune function can be used to determine nanoparticle dosage for patients. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2013/11/131120100311.htm
University of North Carolina School of Medicine. "Probe measuring immune function can be used to determine nanoparticle dosage for patients." ScienceDaily. www.sciencedaily.com/releases/2013/11/131120100311.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) — Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) — A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
Hagel Gets Preview of New High-Tech Projects

Hagel Gets Preview of New High-Tech Projects

AP (Apr. 22, 2014) — Defense Secretary Chuck Hagel is given hands-on demonstrations Tuesday of some of the newest research from DARPA _ the military's Defense Advanced Research Projects Agency program. (April 22) Video provided by AP
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) — NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins